A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants
Identifieur interne : 003240 ( Main/Exploration ); précédent : 003239; suivant : 003241A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants
Auteurs : Lars G. Fritsche [États-Unis] ; Wilmar Igl [Allemagne] ; Jessica N. Cooke Bailey [États-Unis] ; Felix Grassmann [Allemagne] ; Sebanti Sengupta [États-Unis] ; Jennifer L. Bragg-Gresham [États-Unis] ; Kathryn P. Burdon [Australie] ; Scott J. Hebbring [États-Unis] ; Cindy Wen [États-Unis] ; Mathias Gorski [Allemagne] ; Ivana K. Kim [États-Unis] ; David Cho [États-Unis] ; Donald Zack [États-Unis, France] ; Eric Souied [France] ; Hendrik P. N. Scholl [États-Unis, Allemagne] ; Elisa Bala [États-Unis] ; Kristine E. Lee [États-Unis] ; David J. Hunter [États-Unis] ; Rebecca J. Sardell [États-Unis] ; Paul Mitchell [Australie] ; Joanna E. Merriam [États-Unis] ; Valentina Cipriani [Royaume-Uni] ; Joshua D. Hoffman [États-Unis] ; Tina Schick [Allemagne] ; Yara T. E. Lechanteur [Pays-Bas] ; Robyn H. Guymer [Australie] ; Matthew P. Johnson [États-Unis] ; Yingda Jiang [États-Unis] ; Chloe M. Stanton [Royaume-Uni] ; Gabriëlle H. S. Buitendijk [Pays-Bas] ; Xiaowei Zhan [États-Unis] ; Alan M. Kwong [États-Unis] ; Alexis Boleda [États-Unis] ; Matthew Brooks [États-Unis] ; Linn Gieser [États-Unis] ; Rinki Ratnapriya [États-Unis] ; Kari E. Branham [États-Unis] ; Johanna R. Foerster [États-Unis] ; John R. Heckenlively [États-Unis] ; Mohammad I. Othman [États-Unis] ; Brendan J. Vote [Australie] ; Helena Hai Liang [Australie] ; Emmanuelle Souzeau [Australie] ; Ian L. Mcallister [Australie] ; Timothy Isaacs [Australie] ; Janette Hall [Australie] ; Stewart Lake [Australie] ; David A. Mackey [Australie] ; Ian J. Constable [Australie] ; Jamie E. Craig [Australie] ; Terrie E. Kitchner [États-Unis] ; Zhenglin Yang [République populaire de Chine] ; Zhiguang Su [République populaire de Chine] ; Hongrong Luo [États-Unis, République populaire de Chine] ; Daniel Chen [États-Unis] ; Hong Ouyang [États-Unis] ; Ken Flagg [États-Unis] ; Danni Lin [États-Unis] ; Guanping Mao [États-Unis] ; Henry Ferreyra [États-Unis] ; Klaus Stark [Allemagne] ; Claudia N. Von Strachwitz [Allemagne] ; Armin Wolf [Allemagne] ; Caroline Brandl [Allemagne] ; Guenther Rudolph [Allemagne] ; Matthias Olden [Allemagne] ; Margaux A. Morrison [États-Unis] ; Denise J. Morgan [États-Unis] ; Matthew Schu [États-Unis] ; Jeeyun Ahn [Corée du Sud] ; Giuliana Silvestri [Royaume-Uni] ; Evangelia E. Tsironi [Grèce] ; Kyu Hyung Park [Corée du Sud] ; Lindsay A. Farrer [États-Unis] ; Anton Orlin [États-Unis] ; Alexander Brucker [États-Unis] ; Mingyao Li [États-Unis] ; Christine Curcio [États-Unis] ; Saddek Mohand-Saïd [France] ; José-Alain Sahel [Royaume-Uni, France] ; Isabelle Audo [France, Royaume-Uni] ; Mustapha Benchaboune [France] ; Angela J. Cree [Royaume-Uni] ; Christina A. Rennie [Royaume-Uni] ; Srinivas V. Goverdhan [Royaume-Uni] ; Michelle Grunin [Israël] ; Shira Hagbi-Levi [Israël] ; Peter Campochiaro [États-Unis] ; Nicholas Katsanis [États-Unis] ; Frank G. Holz [Allemagne] ; Frédéric Blond [France] ; Hélène Blanché [France] ; Jean-François Deleuze [France] ; Robert P. Igo [États-Unis] ; Barbara Truitt [États-Unis] ; Neal S. Peachey [États-Unis] ; Stacy M. Meuer [États-Unis] ; Chelsea E. Myers [États-Unis] ; Emily L. Moore [États-Unis] ; Ronald Klein [États-Unis] ; Michael A. Hauser [États-Unis] ; Eric A. Postel [États-Unis] ; Monique D. Courtenay [États-Unis] ; Stephen G. Schwartz [États-Unis] ; Jaclyn L. Kovach [États-Unis] ; William K. Scott [États-Unis] ; Gerald Liew [Australie] ; Ava G. T An [Australie] ; Bamini Gopinath [Australie] ; John C. Merriam [États-Unis] ; R. Theodore Smith [États-Unis] ; Jane C. Khan [Australie, Royaume-Uni] ; Humma Shahid [Royaume-Uni] ; Anthony T. Moore [Royaume-Uni, États-Unis] ; J. Allie Mcgrath [États-Unis] ; Reneé Laux [États-Unis] ; Milam A. Brantley [États-Unis] ; Anita Agarwal [États-Unis] ; Lebriz Ersoy [Allemagne] ; Albert Caramoy [Allemagne] ; Thomas Langmann [Allemagne] ; Nicole T. M. Saksens [Pays-Bas] ; Eiko K. De Jong [Pays-Bas] ; Carel B. Hoyng [Pays-Bas] ; Melinda S. Cain [Australie] ; Andrea J. Richardson [Australie] ; Tammy M. Martin [États-Unis] ; John Blangero [États-Unis] ; Daniel E. Weeks [États-Unis] ; Bal Dhillon [Royaume-Uni] ; Cornelia M. Van Duijn [Pays-Bas] ; Kimberly F. Doheny [États-Unis] ; Jane Romm [États-Unis] ; Caroline C. W. Klaver [Pays-Bas] ; Caroline Hayward [Royaume-Uni] ; Michael B. Gorin [États-Unis] ; Michael L. Klein [États-Unis] ; Paul N. Baird [Australie] ; Anneke I. Den Hollander [Pays-Bas] ; Sascha Fauser [Allemagne] ; John R. W. Yates [Royaume-Uni] ; Rando Allikmets [États-Unis] ; Jie Jin Wang [Australie] ; Debra A. Schaumberg [États-Unis] ; Barbara E. K. Klein [États-Unis] ; Stephanie A. Hagstrom [États-Unis] ; Itay Chowers [Israël] ; Andrew J. Lotery [Royaume-Uni] ; Thierry Léveillard [France] ; Kang Zhang [États-Unis, République populaire de Chine] ; Murray H. Brilliant [États-Unis] ; Alex W. Hewitt [Australie] ; Anand Swaroop [États-Unis] ; Emily Y. Chew [États-Unis] ; Margaret A. Pericak-Vance [États-Unis] ; Margaret Deangelis [États-Unis] ; Dwight Stambolian [États-Unis] ; Jonathan L. Haines [États-Unis] ; Sudha K. Iyengar [États-Unis] ; Bernhard H. F. Weber [Allemagne] ; Gonçalo R. Abecasis [États-Unis] ; Iris M. Heid [Allemagne]Source :
- Nature genetics [ 1061-4036 ] ; 2015.
Descripteurs français
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English descriptors
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Abstract
Advanced age-related macular degeneration (AMD) is the leading cause of blindness in the elderly with limited therapeutic options. Here, we report on a study of >12 million variants including 163,714 directly genotyped, most rare, protein-altering variant. Analyzing 16,144 patients and 17,832 controls, we identify 52 independently associated common and rare variants (P < 5×10–8) distributed across 34 loci. While wet and dry AMD subtypes exhibit predominantly shared genetics, we identify the first signal specific to wet AMD, near
Url:
DOI: 10.1038/ng.3448
PubMed: 26691988
PubMed Central: 4745342
Affiliations:
- Allemagne, Australie, Corée du Sud, France, Grèce, Israël, Pays-Bas, Royaume-Uni, République populaire de Chine, États-Unis
- Alabama, Angleterre, Angleterre de l'Est, Bavière, Californie, Caroline du Nord, District de Cologne, District de Haute-Bavière, Floride, Grand Londres, Gueldre, Hollande-Méridionale, Maryland, Massachusetts, Michigan, Nouvelle-Galles du Sud, Ohio, Oregon, Pennsylvanie, Rhénanie-du-Nord-Westphalie, Région capitale de Séoul, Tennessee, Texas, Utah, Victoria (État), Wisconsin, Écosse, État de New York, Île-de-France
- Bonn, Cambridge, Londres, Melbourne, Munich, New York, Nimègue, Paris, Pittsburgh, Portland, Rotterdam, Sydney, Séoul, Édimbourg
- University College de Londres, Université Columbia, Université Pierre-et-Marie-Curie, Université d'Édimbourg, Université de Cambridge, Université de Melbourne, Université de Pittsburgh, Université de Sydney, Université des sciences et de la médecine de l'Oregon
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N." last="Scholl">Hendrik P. N. Scholl</name><affiliation wicri:level="2"><nlm:aff id="A11">Department of Ophthalmology, Wilmer Eye Institute - Johns Hopkins University School of Medicine, Baltimore, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, Wilmer Eye Institute - Johns Hopkins University School of Medicine, Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A17">University of Bonn - Department of Ophthalmology, Bonn, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Bonn - Department of Ophthalmology, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Bala, Elisa" sort="Bala, Elisa" uniqKey="Bala E" first="Elisa" last="Bala">Elisa Bala</name><affiliation wicri:level="2"><nlm:aff id="A18">Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Louis Stokes Cleveland VA Medical Center, Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Lee, Kristine E" sort="Lee, Kristine E" uniqKey="Lee K" first="Kristine E." last="Lee">Kristine E. Lee</name><affiliation wicri:level="2"><nlm:aff id="A19">Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name><affiliation wicri:level="2"><nlm:aff id="A20">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A21">Department of Nutrition, Harvard School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, Harvard School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Sardell, Rebecca J" sort="Sardell, Rebecca J" uniqKey="Sardell R" first="Rebecca J." last="Sardell">Rebecca J. Sardell</name><affiliation wicri:level="2"><nlm:aff id="A22">John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Mitchell, Paul" sort="Mitchell, Paul" uniqKey="Mitchell P" first="Paul" last="Mitchell">Paul Mitchell</name><affiliation wicri:level="4"><nlm:aff id="A23">Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute for Medical Research, University of Sydney, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute for Medical Research, University of Sydney, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Merriam, Joanna E" sort="Merriam, Joanna E" uniqKey="Merriam J" first="Joanna E." last="Merriam">Joanna E. Merriam</name><affiliation wicri:level="2"><nlm:aff id="A24">Department of Ophthalmology Columbia University, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology Columbia University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Cipriani, Valentina" sort="Cipriani, Valentina" uniqKey="Cipriani V" first="Valentina" last="Cipriani">Valentina Cipriani</name><affiliation wicri:level="4"><nlm:aff id="A25">UCL Institute of Ophthalmology, University College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>UCL Institute of Ophthalmology, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="A26">Moorfields Eye Hospital, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Moorfields Eye Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Hoffman, Joshua D" sort="Hoffman, Joshua D" uniqKey="Hoffman J" first="Joshua D." last="Hoffman">Joshua D. Hoffman</name><affiliation wicri:level="2"><nlm:aff id="A27">Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Schick, Tina" sort="Schick, Tina" uniqKey="Schick T" first="Tina" last="Schick">Tina Schick</name><affiliation wicri:level="1"><nlm:aff id="A28">University Hospital of Cologne, Department of Ophthalmology, Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Hospital of Cologne, Department of Ophthalmology, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Lechanteur, Yara T E" sort="Lechanteur, Yara T E" uniqKey="Lechanteur Y" first="Yara T. E." last="Lechanteur">Yara T. E. Lechanteur</name><affiliation wicri:level="3"><nlm:aff id="A29">Department of Ophthalmology, Radboud University Medical Centre, Nijmegen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, Radboud University Medical Centre, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Guymer, Robyn H" sort="Guymer, Robyn H" uniqKey="Guymer R" first="Robyn H." last="Guymer">Robyn H. Guymer</name><affiliation wicri:level="4"><nlm:aff id="A30">Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Johnson, Matthew P" sort="Johnson, Matthew P" uniqKey="Johnson M" first="Matthew P." last="Johnson">Matthew P. Johnson</name><affiliation wicri:level="2"><nlm:aff id="A31">South Texas Diabetes and Obesity Institute, School of Medicine, The University of Texas Rio Grande Valley, Brownsville, TX, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>South Texas Diabetes and Obesity Institute, School of Medicine, The University of Texas Rio Grande Valley, Brownsville, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Jiang, Yingda" sort="Jiang, Yingda" uniqKey="Jiang Y" first="Yingda" last="Jiang">Yingda Jiang</name><affiliation wicri:level="4"><nlm:aff id="A32">Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Stanton, Chloe M" sort="Stanton, Chloe M" uniqKey="Stanton C" first="Chloe M." last="Stanton">Chloe M. Stanton</name><affiliation wicri:level="4"><nlm:aff id="A33">MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Scotland, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Scotland</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Buitendijk, Gabrielle H S" sort="Buitendijk, Gabrielle H S" uniqKey="Buitendijk G" first="Gabriëlle H. S." last="Buitendijk">Gabriëlle H. S. Buitendijk</name><affiliation wicri:level="3"><nlm:aff id="A34">Department of Ophthalmology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A35">Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Zhan, Xiaowei" sort="Zhan, Xiaowei" uniqKey="Zhan X" first="Xiaowei" last="Zhan">Xiaowei Zhan</name><affiliation wicri:level="2"><nlm:aff id="A1">Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A36">Quantitative Biomedical Research Center, Department of Clinical Science, University of Texas Southwestern Medical Center, Dallas, TX, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Quantitative Biomedical Research Center, Department of Clinical Science, University of Texas Southwestern Medical Center, Dallas, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A37">Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Kwong, Alan M" sort="Kwong, Alan M" uniqKey="Kwong A" first="Alan M." last="Kwong">Alan M. Kwong</name><affiliation wicri:level="2"><nlm:aff id="A1">Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Boleda, Alexis" sort="Boleda, Alexis" uniqKey="Boleda A" first="Alexis" last="Boleda">Alexis Boleda</name><affiliation wicri:level="2"><nlm:aff id="A38">Neurobiology Neurodegeneration & Repair Laboratory (N-NRL), National Eye Institute, National Institutes of Health, Bethesda, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Neurobiology Neurodegeneration & Repair Laboratory (N-NRL), National Eye Institute, National Institutes of Health, Bethesda, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Brooks, Matthew" sort="Brooks, Matthew" uniqKey="Brooks M" first="Matthew" last="Brooks">Matthew Brooks</name><affiliation wicri:level="2"><nlm:aff id="A39">Department of Ophthalmology and Visual Sciences, University of Michigan, Kellogg Eye Center, Ann Arbor, MI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, University of Michigan, Kellogg Eye Center, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Gieser, Linn" sort="Gieser, Linn" uniqKey="Gieser L" first="Linn" last="Gieser">Linn Gieser</name><affiliation wicri:level="2"><nlm:aff id="A38">Neurobiology Neurodegeneration & Repair Laboratory (N-NRL), National Eye Institute, National Institutes of Health, Bethesda, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Neurobiology Neurodegeneration & Repair Laboratory (N-NRL), National Eye Institute, National Institutes of Health, Bethesda, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Ratnapriya, Rinki" sort="Ratnapriya, Rinki" uniqKey="Ratnapriya R" first="Rinki" last="Ratnapriya">Rinki Ratnapriya</name><affiliation wicri:level="2"><nlm:aff id="A38">Neurobiology Neurodegeneration & Repair Laboratory (N-NRL), National Eye Institute, National Institutes of Health, Bethesda, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Neurobiology Neurodegeneration & Repair Laboratory (N-NRL), National Eye Institute, National Institutes of Health, Bethesda, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Branham, Kari E" sort="Branham, Kari E" uniqKey="Branham K" first="Kari E." last="Branham">Kari E. Branham</name><affiliation wicri:level="2"><nlm:aff id="A39">Department of Ophthalmology and Visual Sciences, University of Michigan, Kellogg Eye Center, Ann Arbor, MI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, University of Michigan, Kellogg Eye Center, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Foerster, Johanna R" sort="Foerster, Johanna R" uniqKey="Foerster J" first="Johanna R." last="Foerster">Johanna R. Foerster</name><affiliation wicri:level="2"><nlm:aff id="A1">Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Heckenlively, John R" sort="Heckenlively, John R" uniqKey="Heckenlively J" first="John R." last="Heckenlively">John R. Heckenlively</name><affiliation wicri:level="2"><nlm:aff id="A39">Department of Ophthalmology and Visual Sciences, University of Michigan, Kellogg Eye Center, Ann Arbor, MI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, University of Michigan, Kellogg Eye Center, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Othman, Mohammad I" sort="Othman, Mohammad I" uniqKey="Othman M" first="Mohammad I." last="Othman">Mohammad I. Othman</name><affiliation wicri:level="2"><nlm:aff id="A39">Department of Ophthalmology and Visual Sciences, University of Michigan, Kellogg Eye Center, Ann Arbor, MI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, University of Michigan, Kellogg Eye Center, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Vote, Brendan J" sort="Vote, Brendan J" uniqKey="Vote B" first="Brendan J." last="Vote">Brendan J. Vote</name><affiliation wicri:level="1"><nlm:aff id="A6">School of Medicine, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>School of Medicine, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania</wicri:regionArea><wicri:noRegion>Tasmania</wicri:noRegion></affiliation></author><author><name sortKey="Liang, Helena Hai" sort="Liang, Helena Hai" uniqKey="Liang H" first="Helena Hai" last="Liang">Helena Hai Liang</name><affiliation wicri:level="4"><nlm:aff id="A30">Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Souzeau, Emmanuelle" sort="Souzeau, Emmanuelle" uniqKey="Souzeau E" first="Emmanuelle" last="Souzeau">Emmanuelle Souzeau</name><affiliation wicri:level="1"><nlm:aff id="A40">Department of Ophthalmology, Flinders Medical Centre, Flinders University, Adelaide, South Australia, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Ophthalmology, Flinders Medical Centre, Flinders University, Adelaide, South Australia</wicri:regionArea><wicri:noRegion>South Australia</wicri:noRegion></affiliation></author><author><name sortKey="Mcallister, Ian L" sort="Mcallister, Ian L" uniqKey="Mcallister I" first="Ian L." last="Mcallister">Ian L. Mcallister</name><affiliation wicri:level="1"><nlm:aff id="A41">Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Western Australia, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Western Australia</wicri:regionArea><wicri:noRegion>Western Australia</wicri:noRegion></affiliation></author><author><name sortKey="Isaacs, Timothy" sort="Isaacs, Timothy" uniqKey="Isaacs T" first="Timothy" last="Isaacs">Timothy Isaacs</name><affiliation wicri:level="1"><nlm:aff id="A41">Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Western Australia, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Western Australia</wicri:regionArea><wicri:noRegion>Western Australia</wicri:noRegion></affiliation></author><author><name sortKey="Hall, Janette" sort="Hall, Janette" uniqKey="Hall J" first="Janette" last="Hall">Janette Hall</name><affiliation wicri:level="1"><nlm:aff id="A40">Department of Ophthalmology, Flinders Medical Centre, Flinders University, Adelaide, South Australia, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Ophthalmology, Flinders Medical Centre, Flinders University, Adelaide, South Australia</wicri:regionArea><wicri:noRegion>South Australia</wicri:noRegion></affiliation></author><author><name sortKey="Lake, Stewart" sort="Lake, Stewart" uniqKey="Lake S" first="Stewart" last="Lake">Stewart Lake</name><affiliation wicri:level="1"><nlm:aff id="A40">Department of Ophthalmology, Flinders Medical Centre, Flinders University, Adelaide, South Australia, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Ophthalmology, Flinders Medical Centre, Flinders University, Adelaide, South Australia</wicri:regionArea><wicri:noRegion>South Australia</wicri:noRegion></affiliation></author><author><name sortKey="Mackey, David A" sort="Mackey, David A" uniqKey="Mackey D" first="David A." last="Mackey">David A. Mackey</name><affiliation wicri:level="1"><nlm:aff id="A6">School of Medicine, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>School of Medicine, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania</wicri:regionArea><wicri:noRegion>Tasmania</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A30">Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A41">Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Western Australia, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Western Australia</wicri:regionArea><wicri:noRegion>Western Australia</wicri:noRegion></affiliation></author><author><name sortKey="Constable, Ian J" sort="Constable, Ian J" uniqKey="Constable I" first="Ian J." last="Constable">Ian J. Constable</name><affiliation wicri:level="1"><nlm:aff id="A41">Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Western Australia, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Western Australia</wicri:regionArea><wicri:noRegion>Western Australia</wicri:noRegion></affiliation></author><author><name sortKey="Craig, Jamie E" sort="Craig, Jamie E" uniqKey="Craig J" first="Jamie E." last="Craig">Jamie E. Craig</name><affiliation wicri:level="1"><nlm:aff id="A40">Department of Ophthalmology, Flinders Medical Centre, Flinders University, Adelaide, South Australia, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Ophthalmology, Flinders Medical Centre, Flinders University, Adelaide, South Australia</wicri:regionArea><wicri:noRegion>South Australia</wicri:noRegion></affiliation></author><author><name sortKey="Kitchner, Terrie E" sort="Kitchner, Terrie E" uniqKey="Kitchner T" first="Terrie E." last="Kitchner">Terrie E. Kitchner</name><affiliation wicri:level="2"><nlm:aff id="A7">Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, WI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, WI</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author><author><name sortKey="Yang, Zhenglin" sort="Yang, Zhenglin" uniqKey="Yang Z" first="Zhenglin" last="Yang">Zhenglin Yang</name><affiliation wicri:level="1"><nlm:aff id="A42">Sichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Sichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu</wicri:regionArea><wicri:noRegion>Chengdu</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A43">Sichuan Translational Medicine Hospital, Chinese Academy of Sciences, Chengdu, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Sichuan Translational Medicine Hospital, Chinese Academy of Sciences, Chengdu</wicri:regionArea><wicri:noRegion>Chengdu</wicri:noRegion></affiliation></author><author><name sortKey="Su, Zhiguang" sort="Su, Zhiguang" uniqKey="Su Z" first="Zhiguang" last="Su">Zhiguang Su</name><affiliation wicri:level="1"><nlm:aff id="A44">Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan</wicri:regionArea><wicri:noRegion>Sichuan</wicri:noRegion></affiliation></author><author><name sortKey="Luo, Hongrong" sort="Luo, Hongrong" uniqKey="Luo H" first="Hongrong" last="Luo">Hongrong Luo</name><affiliation wicri:level="2"><nlm:aff id="A8">Department of Ophthalmology, University of California San Diego and VA San Diego Health System, La Jolla, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, University of California San Diego and VA San Diego Health System, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A44">Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan</wicri:regionArea><wicri:noRegion>Sichuan</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Daniel" sort="Chen, Daniel" uniqKey="Chen D" first="Daniel" last="Chen">Daniel Chen</name><affiliation wicri:level="2"><nlm:aff id="A8">Department of Ophthalmology, University of California San Diego and VA San Diego Health System, La Jolla, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, University of California San Diego and VA San Diego Health System, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Ouyang, Hong" sort="Ouyang, Hong" uniqKey="Ouyang H" first="Hong" last="Ouyang">Hong Ouyang</name><affiliation wicri:level="2"><nlm:aff id="A8">Department of Ophthalmology, University of California San Diego and VA San Diego Health System, La Jolla, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, University of California San Diego and VA San Diego Health System, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Flagg, Ken" sort="Flagg, Ken" uniqKey="Flagg K" first="Ken" last="Flagg">Ken Flagg</name><affiliation wicri:level="2"><nlm:aff id="A8">Department of Ophthalmology, University of California San Diego and VA San Diego Health System, La Jolla, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, University of California San Diego and VA San Diego Health System, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Lin, Danni" sort="Lin, Danni" uniqKey="Lin D" first="Danni" last="Lin">Danni Lin</name><affiliation wicri:level="2"><nlm:aff id="A8">Department of Ophthalmology, University of California San Diego and VA San Diego Health System, La Jolla, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, University of California San Diego and VA San Diego Health System, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Mao, Guanping" sort="Mao, Guanping" uniqKey="Mao G" first="Guanping" last="Mao">Guanping Mao</name><affiliation wicri:level="2"><nlm:aff id="A8">Department of Ophthalmology, University of California San Diego and VA San Diego Health System, La Jolla, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, University of California San Diego and VA San Diego Health System, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Ferreyra, Henry" sort="Ferreyra, Henry" uniqKey="Ferreyra H" first="Henry" last="Ferreyra">Henry Ferreyra</name><affiliation wicri:level="2"><nlm:aff id="A8">Department of Ophthalmology, University of California San Diego and VA San Diego Health System, La Jolla, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, University of California San Diego and VA San Diego Health System, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Stark, Klaus" sort="Stark, Klaus" uniqKey="Stark K" first="Klaus" last="Stark">Klaus Stark</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Genetic Epidemiology, University of Regensburg, Regensburg</wicri:regionArea><wicri:noRegion>Regensburg</wicri:noRegion><wicri:noRegion>Regensburg</wicri:noRegion><wicri:noRegion>Regensburg</wicri:noRegion></affiliation></author><author><name sortKey="Von Strachwitz, Claudia N" sort="Von Strachwitz, Claudia N" uniqKey="Von Strachwitz C" first="Claudia N." last="Von Strachwitz">Claudia N. Von Strachwitz</name><affiliation wicri:level="1"><nlm:aff id="A45">EyeCentre Southwest, Stuttgart, Baden-Württemberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>EyeCentre Southwest, Stuttgart, Baden-Württemberg</wicri:regionArea><wicri:noRegion>Baden-Württemberg</wicri:noRegion><wicri:noRegion>Baden-Württemberg</wicri:noRegion><wicri:noRegion>Baden-Württemberg</wicri:noRegion></affiliation></author><author><name sortKey="Wolf, Armin" sort="Wolf, Armin" uniqKey="Wolf A" first="Armin" last="Wolf">Armin Wolf</name><affiliation wicri:level="3"><nlm:aff id="A46">University Eye Clinic, Ludwig-Maximilians-University, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Eye Clinic, Ludwig-Maximilians-University, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Brandl, Caroline" sort="Brandl, Caroline" uniqKey="Brandl C" first="Caroline" last="Brandl">Caroline Brandl</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Genetic Epidemiology, University of Regensburg, Regensburg</wicri:regionArea><wicri:noRegion>Regensburg</wicri:noRegion><wicri:noRegion>Regensburg</wicri:noRegion><wicri:noRegion>Regensburg</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">Institute of Human Genetics, University of Regensburg, Regensburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Human Genetics, University of Regensburg, Regensburg</wicri:regionArea><wicri:noRegion>Regensburg</wicri:noRegion><wicri:noRegion>Regensburg</wicri:noRegion><wicri:noRegion>Regensburg</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A47">Department of Ophthalmology, University Hospital Regensburg, Regensburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Ophthalmology, University Hospital Regensburg, Regensburg</wicri:regionArea><wicri:noRegion>Regensburg</wicri:noRegion><wicri:noRegion>Regensburg</wicri:noRegion><wicri:noRegion>Regensburg</wicri:noRegion></affiliation></author><author><name sortKey="Rudolph, Guenther" sort="Rudolph, Guenther" uniqKey="Rudolph G" first="Guenther" last="Rudolph">Guenther Rudolph</name><affiliation wicri:level="3"><nlm:aff id="A46">University Eye Clinic, Ludwig-Maximilians-University, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Eye Clinic, Ludwig-Maximilians-University, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Olden, Matthias" sort="Olden, Matthias" uniqKey="Olden M" first="Matthias" last="Olden">Matthias Olden</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Genetic Epidemiology, University of Regensburg, Regensburg</wicri:regionArea><wicri:noRegion>Regensburg</wicri:noRegion><wicri:noRegion>Regensburg</wicri:noRegion><wicri:noRegion>Regensburg</wicri:noRegion></affiliation></author><author><name sortKey="Morrison, Margaux A" sort="Morrison, Margaux A" uniqKey="Morrison M" first="Margaux A." last="Morrison">Margaux A. Morrison</name><affiliation wicri:level="2"><nlm:aff id="A48">Department of Ophthalmology and Visual Sciences, University of Utah, Salt Lake City, UT, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, University of Utah, Salt Lake City, UT</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="Morgan, Denise J" sort="Morgan, Denise J" uniqKey="Morgan D" first="Denise J." last="Morgan">Denise J. Morgan</name><affiliation wicri:level="2"><nlm:aff id="A48">Department of Ophthalmology and Visual Sciences, University of Utah, Salt Lake City, UT, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, University of Utah, Salt Lake City, UT</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="Schu, Matthew" sort="Schu, Matthew" uniqKey="Schu M" first="Matthew" last="Schu">Matthew Schu</name><affiliation wicri:level="2"><nlm:aff id="A49">Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine and Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine and Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A50">Department of Ophthalmology, Boston University Schools of Medicine and Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, Boston University Schools of Medicine and Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A51">Department of Neurology, Boston University Schools of Medicine and Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Boston University Schools of Medicine and Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A52">Department of Epidemiology, Boston University Schools of Medicine and Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Boston University Schools of Medicine and Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A53">Department of Biostatistics, Boston University Schools of Medicine and Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Boston University Schools of Medicine and Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Ahn, Jeeyun" sort="Ahn, Jeeyun" uniqKey="Ahn J" first="Jeeyun" last="Ahn">Jeeyun Ahn</name><affiliation wicri:level="3"><nlm:aff id="A54">Department of Ophthalmology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Ophthalmology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Silvestri, Giuliana" sort="Silvestri, Giuliana" uniqKey="Silvestri G" first="Giuliana" last="Silvestri">Giuliana Silvestri</name><affiliation wicri:level="1"><nlm:aff id="A55">Centre for Experimental Medicine, Queen's University, Belfast, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Experimental Medicine, Queen's University, Belfast</wicri:regionArea><wicri:noRegion>Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Tsironi, Evangelia E" sort="Tsironi, Evangelia E" uniqKey="Tsironi E" first="Evangelia E." last="Tsironi">Evangelia E. Tsironi</name><affiliation wicri:level="1"><nlm:aff id="A56">Department of Ophthalmology, University of Thessaly, School of Medicine, Larissa, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Ophthalmology, University of Thessaly, School of Medicine, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation></author><author><name sortKey="Park, Kyu Hyung" sort="Park, Kyu Hyung" uniqKey="Park K" first="Kyu Hyung" last="Park">Kyu Hyung Park</name><affiliation wicri:level="1"><nlm:aff id="A57">Department of Ophthalmology, Seoul National University Bundang Hospital, Seongnam, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Ophthalmology, Seoul National University Bundang Hospital, Seongnam</wicri:regionArea><wicri:noRegion>Seongnam</wicri:noRegion></affiliation></author><author><name sortKey="Farrer, Lindsay A" sort="Farrer, Lindsay A" uniqKey="Farrer L" first="Lindsay A." last="Farrer">Lindsay A. Farrer</name><affiliation wicri:level="2"><nlm:aff id="A49">Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine and Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine and Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A50">Department of Ophthalmology, Boston University Schools of Medicine and Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, Boston University Schools of Medicine and Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A51">Department of Neurology, Boston University Schools of Medicine and Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Boston University Schools of Medicine and Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A52">Department of Epidemiology, Boston University Schools of Medicine and Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Boston University Schools of Medicine and Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A53">Department of Biostatistics, Boston University Schools of Medicine and Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Boston University Schools of Medicine and Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Orlin, Anton" sort="Orlin, Anton" uniqKey="Orlin A" first="Anton" last="Orlin">Anton Orlin</name><affiliation wicri:level="2"><nlm:aff id="A58">Department of Ophthalmology, Weill Cornell Medical College, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, Weill Cornell Medical College, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Brucker, Alexander" sort="Brucker, Alexander" uniqKey="Brucker A" first="Alexander" last="Brucker">Alexander Brucker</name><affiliation wicri:level="2"><nlm:aff id="A59">Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Li, Mingyao" sort="Li, Mingyao" uniqKey="Li M" first="Mingyao" last="Li">Mingyao Li</name><affiliation wicri:level="2"><nlm:aff id="A60">Department of Biostatistics and Epidemiology University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics and Epidemiology University of Pennsylvania Perelman School of Medicine, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Curcio, Christine" sort="Curcio, Christine" uniqKey="Curcio C" first="Christine" last="Curcio">Christine Curcio</name><affiliation wicri:level="2"><nlm:aff id="A61">Department of Ophthalmology, The University of Alabama at Birmingham, Birmingham, AL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, The University of Alabama at Birmingham, Birmingham, AL</wicri:regionArea><placeName><region type="state">Alabama</region></placeName></affiliation></author><author><name sortKey="Mohand Said, Saddek" sort="Mohand Said, Saddek" uniqKey="Mohand Said S" first="Saddek" last="Mohand-Saïd">Saddek Mohand-Saïd</name><affiliation wicri:level="3"><nlm:aff id="A62">INSERM, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A63">Institut de la Vision, Department of Genetics, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut de la Vision, Department of Genetics, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A64">CNRS, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A65">Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Sahel, Jose Alain" sort="Sahel, Jose Alain" uniqKey="Sahel J" first="José-Alain" last="Sahel">José-Alain Sahel</name><affiliation wicri:level="4"><nlm:aff id="A25">UCL Institute of Ophthalmology, University College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>UCL Institute of Ophthalmology, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="A62">INSERM, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A63">Institut de la Vision, Department of Genetics, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut de la Vision, Department of Genetics, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A64">CNRS, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A65">Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A66">Fondation Ophtalmologique Adolphe de Rothschild, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Fondation Ophtalmologique Adolphe de Rothschild, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A67">Académie des Sciences–Institut de France, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Académie des Sciences–Institut de France, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Audo, Isabelle" sort="Audo, Isabelle" uniqKey="Audo I" first="Isabelle" last="Audo">Isabelle Audo</name><affiliation wicri:level="3"><nlm:aff id="A62">INSERM, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A63">Institut de la Vision, Department of Genetics, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut de la Vision, Department of Genetics, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A64">CNRS, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A68">Department of Molecular Genetics, Institute of Ophthalmology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Molecular Genetics, Institute of Ophthalmology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Benchaboune, Mustapha" sort="Benchaboune, Mustapha" uniqKey="Benchaboune M" first="Mustapha" last="Benchaboune">Mustapha Benchaboune</name><affiliation wicri:level="3"><nlm:aff id="A65">Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Cree, Angela J" sort="Cree, Angela J" uniqKey="Cree A" first="Angela J." last="Cree">Angela J. Cree</name><affiliation wicri:level="1"><nlm:aff id="A69">Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton</wicri:regionArea><wicri:noRegion>University of Southampton</wicri:noRegion></affiliation></author><author><name sortKey="Rennie, Christina A" sort="Rennie, Christina A" uniqKey="Rennie C" first="Christina A." last="Rennie">Christina A. Rennie</name><affiliation wicri:level="1"><nlm:aff id="A70">University Hospital Southampton, Southampton, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University Hospital Southampton, Southampton</wicri:regionArea><wicri:noRegion>Southampton</wicri:noRegion></affiliation></author><author><name sortKey="Goverdhan, Srinivas V" sort="Goverdhan, Srinivas V" uniqKey="Goverdhan S" first="Srinivas V." last="Goverdhan">Srinivas V. Goverdhan</name><affiliation wicri:level="1"><nlm:aff id="A69">Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton</wicri:regionArea><wicri:noRegion>University of Southampton</wicri:noRegion></affiliation></author><author><name sortKey="Grunin, Michelle" sort="Grunin, Michelle" uniqKey="Grunin M" first="Michelle" last="Grunin">Michelle Grunin</name><affiliation wicri:level="1"><nlm:aff id="A71">Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem</wicri:regionArea><wicri:noRegion>Jerusalem</wicri:noRegion></affiliation></author><author><name sortKey="Hagbi Levi, Shira" sort="Hagbi Levi, Shira" uniqKey="Hagbi Levi S" first="Shira" last="Hagbi-Levi">Shira Hagbi-Levi</name><affiliation wicri:level="1"><nlm:aff id="A71">Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem</wicri:regionArea><wicri:noRegion>Jerusalem</wicri:noRegion></affiliation></author><author><name sortKey="Campochiaro, Peter" sort="Campochiaro, Peter" uniqKey="Campochiaro P" first="Peter" last="Campochiaro">Peter Campochiaro</name><affiliation wicri:level="2"><nlm:aff id="A11">Department of Ophthalmology, Wilmer Eye Institute - Johns Hopkins University School of Medicine, Baltimore, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, Wilmer Eye Institute - Johns Hopkins University School of Medicine, Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A13">Department of Neuroscience - Johns Hopkins University School of Medicine, Baltimore, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience - Johns Hopkins University School of Medicine, Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Katsanis, Nicholas" sort="Katsanis, Nicholas" uniqKey="Katsanis N" first="Nicholas" last="Katsanis">Nicholas Katsanis</name><affiliation wicri:level="2"><nlm:aff id="A72">Center for Human Disease Modeling, Duke University, Durham, NC, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Human Disease Modeling, Duke University, Durham, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A73">Department of Cell Biology, Duke University, Durham, NC, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cell Biology, Duke University, Durham, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A74">Department of Pediatrics, Duke University, Durham, NC, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, Duke University, Durham, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Holz, Frank G" sort="Holz, Frank G" uniqKey="Holz F" first="Frank G." last="Holz">Frank G. Holz</name><affiliation wicri:level="3"><nlm:aff id="A17">University of Bonn - Department of Ophthalmology, Bonn, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Bonn - Department of Ophthalmology, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Blond, Frederic" sort="Blond, Frederic" uniqKey="Blond F" first="Frédéric" last="Blond">Frédéric Blond</name><affiliation wicri:level="3"><nlm:aff id="A62">INSERM, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A63">Institut de la Vision, Department of Genetics, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut de la Vision, Department of Genetics, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A64">CNRS, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Blanche, Helene" sort="Blanche, Helene" uniqKey="Blanche H" first="Hélène" last="Blanché">Hélène Blanché</name><affiliation wicri:level="1"><nlm:aff id="A75">CEPH Fondation Jean Dausset Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CEPH Fondation Jean Dausset Paris</wicri:regionArea></affiliation></author><author><name sortKey="Deleuze, Jean Francois" sort="Deleuze, Jean Francois" uniqKey="Deleuze J" first="Jean-François" last="Deleuze">Jean-François Deleuze</name><affiliation wicri:level="1"><nlm:aff id="A75">CEPH Fondation Jean Dausset Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CEPH Fondation Jean Dausset Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A76">CEA – IG – Centre National de Génotypage Evry Cédex, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CEA – IG – Centre National de Génotypage Evry Cédex</wicri:regionArea></affiliation></author><author><name sortKey="Igo, Robert P" sort="Igo, Robert P" uniqKey="Igo R" first="Robert P." last="Igo">Robert P. Igo</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Truitt, Barbara" sort="Truitt, Barbara" uniqKey="Truitt B" first="Barbara" last="Truitt">Barbara Truitt</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Peachey, Neal S" sort="Peachey, Neal S" uniqKey="Peachey N" first="Neal S." last="Peachey">Neal S. Peachey</name><affiliation wicri:level="2"><nlm:aff id="A18">Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Louis Stokes Cleveland VA Medical Center, Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A77">Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cole Eye Institute, Cleveland Clinic, Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Meuer, Stacy M" sort="Meuer, Stacy M" uniqKey="Meuer S" first="Stacy M." last="Meuer">Stacy M. Meuer</name><affiliation wicri:level="2"><nlm:aff id="A19">Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author><author><name sortKey="Myers, Chelsea E" sort="Myers, Chelsea E" uniqKey="Myers C" first="Chelsea E." last="Myers">Chelsea E. Myers</name><affiliation wicri:level="2"><nlm:aff id="A19">Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author><author><name sortKey="Moore, Emily L" sort="Moore, Emily L" uniqKey="Moore E" first="Emily L." last="Moore">Emily L. Moore</name><affiliation wicri:level="2"><nlm:aff id="A19">Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author><author><name sortKey="Klein, Ronald" sort="Klein, Ronald" uniqKey="Klein R" first="Ronald" last="Klein">Ronald Klein</name><affiliation wicri:level="2"><nlm:aff id="A19">Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author><author><name sortKey="Hauser, Michael A" sort="Hauser, Michael A" uniqKey="Hauser M" first="Michael A." last="Hauser">Michael A. Hauser</name><affiliation wicri:level="2"><nlm:aff id="A78">Department of Ophthalmology, Duke University Medical Center, Durham, NC, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, Duke University Medical Center, Durham, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A79">Department of Medicine, Duke University Medical Center, Durham, NC, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Duke University Medical Center, Durham, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A80">Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Postel, Eric A" sort="Postel, Eric A" uniqKey="Postel E" first="Eric A." last="Postel">Eric A. Postel</name><affiliation wicri:level="2"><nlm:aff id="A78">Department of Ophthalmology, Duke University Medical Center, Durham, NC, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, Duke University Medical Center, Durham, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Courtenay, Monique D" sort="Courtenay, Monique D" uniqKey="Courtenay M" first="Monique D." last="Courtenay">Monique D. Courtenay</name><affiliation wicri:level="2"><nlm:aff id="A22">John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Schwartz, Stephen G" sort="Schwartz, Stephen G" uniqKey="Schwartz S" first="Stephen G." last="Schwartz">Stephen G. Schwartz</name><affiliation wicri:level="2"><nlm:aff id="A81">Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Naples, FL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Naples, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Kovach, Jaclyn L" sort="Kovach, Jaclyn L" uniqKey="Kovach J" first="Jaclyn L." last="Kovach">Jaclyn L. Kovach</name><affiliation wicri:level="2"><nlm:aff id="A81">Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Naples, FL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Naples, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Scott, William K" sort="Scott, William K" uniqKey="Scott W" first="William K." last="Scott">William K. Scott</name><affiliation wicri:level="2"><nlm:aff id="A22">John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Liew, Gerald" sort="Liew, Gerald" uniqKey="Liew G" first="Gerald" last="Liew">Gerald Liew</name><affiliation wicri:level="4"><nlm:aff id="A23">Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute for Medical Research, University of Sydney, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute for Medical Research, University of Sydney, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="T An, Ava G" sort="T An, Ava G" uniqKey="T An A" first="Ava G." last="T An">Ava G. T An</name><affiliation wicri:level="4"><nlm:aff id="A23">Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute for Medical Research, University of Sydney, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute for Medical Research, University of Sydney, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Gopinath, Bamini" sort="Gopinath, Bamini" uniqKey="Gopinath B" first="Bamini" last="Gopinath">Bamini Gopinath</name><affiliation wicri:level="4"><nlm:aff id="A23">Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute for Medical Research, University of Sydney, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute for Medical Research, University of Sydney, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Merriam, John C" sort="Merriam, John C" uniqKey="Merriam J" first="John C." last="Merriam">John C. Merriam</name><affiliation wicri:level="2"><nlm:aff id="A24">Department of Ophthalmology Columbia University, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology Columbia University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Smith, R Theodore" sort="Smith, R Theodore" uniqKey="Smith R" first="R. Theodore" last="Smith">R. Theodore Smith</name><affiliation wicri:level="2"><nlm:aff id="A24">Department of Ophthalmology Columbia University, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology Columbia University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A82">Department of Ophthalmology, NYU School of Medicine, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, NYU School of Medicine, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Khan, Jane C" sort="Khan, Jane C" uniqKey="Khan J" first="Jane C." last="Khan">Jane C. Khan</name><affiliation wicri:level="1"><nlm:aff id="A41">Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Western Australia, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Western Australia</wicri:regionArea><wicri:noRegion>Western Australia</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A83">Department of Ophthalmology, Royal Perth Hospital, Perth, Western Australia, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Ophthalmology, Royal Perth Hospital, Perth, Western Australia</wicri:regionArea><wicri:noRegion>Western Australia</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A84">Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Shahid, Humma" sort="Shahid, Humma" uniqKey="Shahid H" first="Humma" last="Shahid">Humma Shahid</name><affiliation wicri:level="4"><nlm:aff id="A84">Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A85">Department of Ophthalmology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Ophthalmology, Cambridge University Hospitals NHS Foundation Trust, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Moore, Anthony T" sort="Moore, Anthony T" uniqKey="Moore A" first="Anthony T." last="Moore">Anthony T. Moore</name><affiliation wicri:level="4"><nlm:aff id="A25">UCL Institute of Ophthalmology, University College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>UCL Institute of Ophthalmology, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="A26">Moorfields Eye Hospital, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Moorfields Eye Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A86">Department of Ophthalmology UCSF Medical School, San Francisco, CA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Ophthalmology UCSF Medical School, San Francisco</wicri:cityArea></affiliation></author><author><name sortKey="Mcgrath, J Allie" sort="Mcgrath, J Allie" uniqKey="Mcgrath J" first="J. Allie" last="Mcgrath">J. Allie Mcgrath</name><affiliation wicri:level="2"><nlm:aff id="A27">Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Laux, Renee" sort="Laux, Renee" uniqKey="Laux R" first="Reneé" last="Laux">Reneé Laux</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Brantley, Milam A" sort="Brantley, Milam A" uniqKey="Brantley M" first="Milam A." last="Brantley">Milam A. Brantley</name><affiliation wicri:level="2"><nlm:aff id="A87">Department of Ophthalmology and Visual Sciences, Vanderbilt University, Nashville, TN, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, Vanderbilt University, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Agarwal, Anita" sort="Agarwal, Anita" uniqKey="Agarwal A" first="Anita" last="Agarwal">Anita Agarwal</name><affiliation wicri:level="2"><nlm:aff id="A87">Department of Ophthalmology and Visual Sciences, Vanderbilt University, Nashville, TN, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, Vanderbilt University, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Ersoy, Lebriz" sort="Ersoy, Lebriz" uniqKey="Ersoy L" first="Lebriz" last="Ersoy">Lebriz Ersoy</name><affiliation wicri:level="1"><nlm:aff id="A28">University Hospital of Cologne, Department of Ophthalmology, Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Hospital of Cologne, Department of Ophthalmology, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Caramoy, Albert" sort="Caramoy, Albert" uniqKey="Caramoy A" first="Albert" last="Caramoy">Albert Caramoy</name><affiliation wicri:level="1"><nlm:aff id="A28">University Hospital of Cologne, Department of Ophthalmology, Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Hospital of Cologne, Department of Ophthalmology, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Langmann, Thomas" sort="Langmann, Thomas" uniqKey="Langmann T" first="Thomas" last="Langmann">Thomas Langmann</name><affiliation wicri:level="1"><nlm:aff id="A28">University Hospital of Cologne, Department of Ophthalmology, Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Hospital of Cologne, Department of Ophthalmology, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Saksens, Nicole T M" sort="Saksens, Nicole T M" uniqKey="Saksens N" first="Nicole T. M." last="Saksens">Nicole T. M. Saksens</name><affiliation wicri:level="3"><nlm:aff id="A29">Department of Ophthalmology, Radboud University Medical Centre, Nijmegen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, Radboud University Medical Centre, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="De Jong, Eiko K" sort="De Jong, Eiko K" uniqKey="De Jong E" first="Eiko K." last="De Jong">Eiko K. De Jong</name><affiliation wicri:level="3"><nlm:aff id="A29">Department of Ophthalmology, Radboud University Medical Centre, Nijmegen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, Radboud University Medical Centre, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Hoyng, Carel B" sort="Hoyng, Carel B" uniqKey="Hoyng C" first="Carel B." last="Hoyng">Carel B. Hoyng</name><affiliation wicri:level="3"><nlm:aff id="A29">Department of Ophthalmology, Radboud University Medical Centre, Nijmegen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, Radboud University Medical Centre, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Cain, Melinda S" sort="Cain, Melinda S" uniqKey="Cain M" first="Melinda S." last="Cain">Melinda S. Cain</name><affiliation wicri:level="4"><nlm:aff id="A30">Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Richardson, Andrea J" sort="Richardson, Andrea J" uniqKey="Richardson A" first="Andrea J." last="Richardson">Andrea J. Richardson</name><affiliation wicri:level="4"><nlm:aff id="A30">Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Martin, Tammy M" sort="Martin, Tammy M" uniqKey="Martin T" first="Tammy M." last="Martin">Tammy M. Martin</name><affiliation wicri:level="4"><nlm:aff id="A88">Casey Eye Institute, Oregon Health & Science University, Portland OR, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Casey Eye Institute, Oregon Health & Science University, Portland OR</wicri:regionArea><orgName type="university">Université des sciences et de la médecine de l'Oregon</orgName><placeName><settlement type="city">Portland</settlement><region type="state">Oregon</region></placeName></affiliation></author><author><name sortKey="Blangero, John" sort="Blangero, John" uniqKey="Blangero J" first="John" last="Blangero">John Blangero</name><affiliation wicri:level="2"><nlm:aff id="A31">South Texas Diabetes and Obesity Institute, School of Medicine, The University of Texas Rio Grande Valley, Brownsville, TX, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>South Texas Diabetes and Obesity Institute, School of Medicine, The University of Texas Rio Grande Valley, Brownsville, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Weeks, Daniel E" sort="Weeks, Daniel E" uniqKey="Weeks D" first="Daniel E." last="Weeks">Daniel E. Weeks</name><affiliation wicri:level="4"><nlm:aff id="A32">Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A89">Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Dhillon, Bal" sort="Dhillon, Bal" uniqKey="Dhillon B" first="Bal" last="Dhillon">Bal Dhillon</name><affiliation wicri:level="4"><nlm:aff id="A90">School of Clinical Sciences University of Edinburgh, Scotland, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Clinical Sciences University of Edinburgh, Scotland</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M." last="Van Duijn">Cornelia M. Van Duijn</name><affiliation wicri:level="3"><nlm:aff id="A35">Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Doheny, Kimberly F" sort="Doheny, Kimberly F" uniqKey="Doheny K" first="Kimberly F." last="Doheny">Kimberly F. Doheny</name><affiliation wicri:level="2"><nlm:aff id="A91">Center for Inherited Disease Research (CIDR) Institute of Genetic Medicine Johns Hopkins University School of Medicine Baltimore, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Inherited Disease Research (CIDR) Institute of Genetic Medicine Johns Hopkins University School of Medicine Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Romm, Jane" sort="Romm, Jane" uniqKey="Romm J" first="Jane" last="Romm">Jane Romm</name><affiliation wicri:level="2"><nlm:aff id="A91">Center for Inherited Disease Research (CIDR) Institute of Genetic Medicine Johns Hopkins University School of Medicine Baltimore, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Inherited Disease Research (CIDR) Institute of Genetic Medicine Johns Hopkins University School of Medicine Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Klaver, Caroline C W" sort="Klaver, Caroline C W" uniqKey="Klaver C" first="Caroline C. W." last="Klaver">Caroline C. W. Klaver</name><affiliation wicri:level="3"><nlm:aff id="A34">Department of Ophthalmology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A35">Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name><affiliation wicri:level="4"><nlm:aff id="A33">MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Scotland, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Scotland</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Gorin, Michael B" sort="Gorin, Michael B" uniqKey="Gorin M" first="Michael B." last="Gorin">Michael B. Gorin</name><affiliation wicri:level="2"><nlm:aff id="A92">Department of Ophthalmology, David Geffen School of Medicine—UCLA, Stein Eye Institute, Los Angeles, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, David Geffen School of Medicine—UCLA, Stein Eye Institute, Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A93">Department of Human Genetics, David Geffen School of Medicine—UCLA, Los Angeles, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Human Genetics, David Geffen School of Medicine—UCLA, Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Klein, Michael L" sort="Klein, Michael L" uniqKey="Klein M" first="Michael L." last="Klein">Michael L. Klein</name><affiliation wicri:level="4"><nlm:aff id="A88">Casey Eye Institute, Oregon Health & Science University, Portland OR, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Casey Eye Institute, Oregon Health & Science University, Portland OR</wicri:regionArea><orgName type="university">Université des sciences et de la médecine de l'Oregon</orgName><placeName><settlement type="city">Portland</settlement><region type="state">Oregon</region></placeName></affiliation></author><author><name sortKey="Baird, Paul N" sort="Baird, Paul N" uniqKey="Baird P" first="Paul N." last="Baird">Paul N. Baird</name><affiliation wicri:level="4"><nlm:aff id="A30">Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Den Hollander, Anneke I" sort="Den Hollander, Anneke I" uniqKey="Den Hollander A" first="Anneke I." last="Den Hollander">Anneke I. Den Hollander</name><affiliation wicri:level="3"><nlm:aff id="A29">Department of Ophthalmology, Radboud University Medical Centre, Nijmegen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, Radboud University Medical Centre, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A94">Department of Human Genetics, Radboud University Medical Centre, Nijmegen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Human Genetics, Radboud University Medical Centre, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Fauser, Sascha" sort="Fauser, Sascha" uniqKey="Fauser S" first="Sascha" last="Fauser">Sascha Fauser</name><affiliation wicri:level="1"><nlm:aff id="A28">University Hospital of Cologne, Department of Ophthalmology, Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Hospital of Cologne, Department of Ophthalmology, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Yates, John R W" sort="Yates, John R W" uniqKey="Yates J" first="John R. W." last="Yates">John R. W. Yates</name><affiliation wicri:level="4"><nlm:aff id="A25">UCL Institute of Ophthalmology, University College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>UCL Institute of Ophthalmology, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="A26">Moorfields Eye Hospital, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Moorfields Eye Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A84">Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Allikmets, Rando" sort="Allikmets, Rando" uniqKey="Allikmets R" first="Rando" last="Allikmets">Rando Allikmets</name><affiliation wicri:level="2"><nlm:aff id="A24">Department of Ophthalmology Columbia University, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology Columbia University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A95">Department of Pathology & Cell Biology, Columbia University, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology & Cell Biology, Columbia University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Wang, Jie Jin" sort="Wang, Jie Jin" uniqKey="Wang J" first="Jie Jin" last="Wang">Jie Jin Wang</name><affiliation wicri:level="4"><nlm:aff id="A23">Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute for Medical Research, University of Sydney, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute for Medical Research, University of Sydney, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Schaumberg, Debra A" sort="Schaumberg, Debra A" uniqKey="Schaumberg D" first="Debra A." last="Schaumberg">Debra A. Schaumberg</name><affiliation wicri:level="2"><nlm:aff id="A20">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A96">Center for Translational Medicine, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Translational Medicine, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A97">Division of Preventive Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Preventive Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Klein, Barbara E K" sort="Klein, Barbara E K" uniqKey="Klein B" first="Barbara E. K." last="Klein">Barbara E. K. Klein</name><affiliation wicri:level="2"><nlm:aff id="A19">Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author><author><name sortKey="Hagstrom, Stephanie A" sort="Hagstrom, Stephanie A" uniqKey="Hagstrom S" first="Stephanie A." last="Hagstrom">Stephanie A. Hagstrom</name><affiliation wicri:level="2"><nlm:aff id="A77">Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cole Eye Institute, Cleveland Clinic, Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Chowers, Itay" sort="Chowers, Itay" uniqKey="Chowers I" first="Itay" last="Chowers">Itay Chowers</name><affiliation wicri:level="1"><nlm:aff id="A71">Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem</wicri:regionArea><wicri:noRegion>Jerusalem</wicri:noRegion></affiliation></author><author><name sortKey="Lotery, Andrew J" sort="Lotery, Andrew J" uniqKey="Lotery A" first="Andrew J." last="Lotery">Andrew J. Lotery</name><affiliation wicri:level="1"><nlm:aff id="A69">Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton</wicri:regionArea><wicri:noRegion>University of Southampton</wicri:noRegion></affiliation></author><author><name sortKey="Leveillard, Thierry" sort="Leveillard, Thierry" uniqKey="Leveillard T" first="Thierry" last="Léveillard">Thierry Léveillard</name><affiliation wicri:level="3"><nlm:aff id="A62">INSERM, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A63">Institut de la Vision, Department of Genetics, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut de la Vision, Department of Genetics, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A64">CNRS, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Zhang, Kang" sort="Zhang, Kang" uniqKey="Zhang K" first="Kang" last="Zhang">Kang Zhang</name><affiliation wicri:level="2"><nlm:aff id="A8">Department of Ophthalmology, University of California San Diego and VA San Diego Health System, La Jolla, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, University of California San Diego and VA San Diego Health System, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A44">Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan</wicri:regionArea><wicri:noRegion>Sichuan</wicri:noRegion></affiliation></author><author><name sortKey="Brilliant, Murray H" sort="Brilliant, Murray H" uniqKey="Brilliant M" first="Murray H." last="Brilliant">Murray H. Brilliant</name><affiliation wicri:level="2"><nlm:aff id="A7">Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, WI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, WI</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author><author><name sortKey="Hewitt, Alex W" sort="Hewitt, Alex W" uniqKey="Hewitt A" first="Alex W." last="Hewitt">Alex W. Hewitt</name><affiliation wicri:level="1"><nlm:aff id="A6">School of Medicine, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>School of Medicine, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania</wicri:regionArea><wicri:noRegion>Tasmania</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A30">Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A41">Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Western Australia, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Western Australia</wicri:regionArea><wicri:noRegion>Western Australia</wicri:noRegion></affiliation></author><author><name sortKey="Swaroop, Anand" sort="Swaroop, Anand" uniqKey="Swaroop A" first="Anand" last="Swaroop">Anand Swaroop</name><affiliation wicri:level="2"><nlm:aff id="A38">Neurobiology Neurodegeneration & Repair Laboratory (N-NRL), National Eye Institute, National Institutes of Health, Bethesda, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Neurobiology Neurodegeneration & Repair Laboratory (N-NRL), National Eye Institute, National Institutes of Health, Bethesda, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Chew, Emily Y" sort="Chew, Emily Y" uniqKey="Chew E" first="Emily Y." last="Chew">Emily Y. Chew</name><affiliation wicri:level="2"><nlm:aff id="A98">Division of Epidemiology and Clinical Applications, Clinical Trials Branch, National Eye Institute, National Institutes of Health, Bethesda, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Epidemiology and Clinical Applications, Clinical Trials Branch, National Eye Institute, National Institutes of Health, Bethesda, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Pericak Vance, Margaret A" sort="Pericak Vance, Margaret A" uniqKey="Pericak Vance M" first="Margaret A." last="Pericak-Vance">Margaret A. Pericak-Vance</name><affiliation wicri:level="2"><nlm:aff id="A22">John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Deangelis, Margaret" sort="Deangelis, Margaret" uniqKey="Deangelis M" first="Margaret" last="Deangelis">Margaret Deangelis</name><affiliation wicri:level="2"><nlm:aff id="A48">Department of Ophthalmology and Visual Sciences, University of Utah, Salt Lake City, UT, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, University of Utah, Salt Lake City, UT</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="Stambolian, Dwight" sort="Stambolian, Dwight" uniqKey="Stambolian D" first="Dwight" last="Stambolian">Dwight Stambolian</name><affiliation wicri:level="2"><nlm:aff id="A10">Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Haines, Jonathan L" sort="Haines, Jonathan L" uniqKey="Haines J" first="Jonathan L." last="Haines">Jonathan L. Haines</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A99">Institute for Computational Biology, Case Western Reserve University School of Medicine, Cleveland, OH, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Computational Biology, Case Western Reserve University School of Medicine, Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Iyengar, Sudha K" sort="Iyengar, Sudha K" uniqKey="Iyengar S" first="Sudha K." last="Iyengar">Sudha K. Iyengar</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Weber, Bernhard H F" sort="Weber, Bernhard H F" uniqKey="Weber B" first="Bernhard H. F." last="Weber">Bernhard H. F. Weber</name><affiliation wicri:level="1"><nlm:aff id="A4">Institute of Human Genetics, University of Regensburg, Regensburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Human Genetics, University of Regensburg, Regensburg</wicri:regionArea><wicri:noRegion>Regensburg</wicri:noRegion><wicri:noRegion>Regensburg</wicri:noRegion><wicri:noRegion>Regensburg</wicri:noRegion></affiliation></author><author><name sortKey="Abecasis, Goncalo R" sort="Abecasis, Goncalo R" uniqKey="Abecasis G" first="Gonçalo R." last="Abecasis">Gonçalo R. Abecasis</name><affiliation wicri:level="2"><nlm:aff id="A1">Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Heid, Iris M" sort="Heid, Iris M" uniqKey="Heid I" first="Iris M." last="Heid">Iris M. Heid</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Genetic Epidemiology, University of Regensburg, Regensburg</wicri:regionArea><wicri:noRegion>Regensburg</wicri:noRegion><wicri:noRegion>Regensburg</wicri:noRegion><wicri:noRegion>Regensburg</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26691988</idno><idno type="pmc">4745342</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745342</idno><idno type="RBID">PMC:4745342</idno><idno type="doi">10.1038/ng.3448</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">002E44</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002E44</idno><idno type="wicri:Area/Pmc/Curation">002C94</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002C94</idno><idno type="wicri:Area/Pmc/Checkpoint">001217</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001217</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">002312</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002312</idno><idno type="wicri:Area/PubMed/Curation">002286</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002286</idno><idno type="wicri:Area/PubMed/Checkpoint">002286</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002286</idno><idno type="wicri:Area/Ncbi/Merge">002F02</idno><idno type="wicri:Area/Ncbi/Curation">002F02</idno><idno type="wicri:Area/Ncbi/Checkpoint">002F02</idno><idno type="wicri:doubleKey">1061-4036:2015:Fritsche L:a:large:genome</idno><idno type="wicri:Area/Main/Merge">003241</idno><idno type="wicri:Area/Main/Curation">003240</idno><idno type="wicri:Area/Main/Exploration">003240</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants</title><author><name sortKey="Fritsche, Lars G" sort="Fritsche, Lars G" uniqKey="Fritsche L" first="Lars G." last="Fritsche">Lars G. Fritsche</name><affiliation wicri:level="2"><nlm:aff id="A1">Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Igl, Wilmar" sort="Igl, Wilmar" uniqKey="Igl W" first="Wilmar" last="Igl">Wilmar Igl</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Genetic Epidemiology, University of Regensburg, Regensburg</wicri:regionArea><wicri:noRegion>Regensburg</wicri:noRegion><wicri:noRegion>Regensburg</wicri:noRegion><wicri:noRegion>Regensburg</wicri:noRegion></affiliation></author><author><name sortKey="Cooke Bailey, Jessica N" sort="Cooke Bailey, Jessica N" uniqKey="Cooke Bailey J" first="Jessica N." last="Cooke Bailey">Jessica N. Cooke Bailey</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Grassmann, Felix" sort="Grassmann, Felix" uniqKey="Grassmann F" first="Felix" last="Grassmann">Felix Grassmann</name><affiliation wicri:level="1"><nlm:aff id="A4">Institute of Human Genetics, University of Regensburg, Regensburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Human Genetics, University of Regensburg, Regensburg</wicri:regionArea><wicri:noRegion>Regensburg</wicri:noRegion><wicri:noRegion>Regensburg</wicri:noRegion><wicri:noRegion>Regensburg</wicri:noRegion></affiliation></author><author><name sortKey="Sengupta, Sebanti" sort="Sengupta, Sebanti" uniqKey="Sengupta S" first="Sebanti" last="Sengupta">Sebanti Sengupta</name><affiliation wicri:level="2"><nlm:aff id="A1">Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Bragg Gresham, Jennifer L" sort="Bragg Gresham, Jennifer L" uniqKey="Bragg Gresham J" first="Jennifer L." last="Bragg-Gresham">Jennifer L. Bragg-Gresham</name><affiliation wicri:level="2"><nlm:aff id="A1">Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A5">Kidney Epidemiology and Cost Center, Department of Internal Medicine - Nephrology, University of Michigan, Ann Arbor, MI 48109, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Kidney Epidemiology and Cost Center, Department of Internal Medicine - Nephrology, University of Michigan, Ann Arbor, MI 48109</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Burdon, Kathryn P" sort="Burdon, Kathryn P" uniqKey="Burdon K" first="Kathryn P." last="Burdon">Kathryn P. Burdon</name><affiliation wicri:level="1"><nlm:aff id="A6">School of Medicine, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>School of Medicine, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania</wicri:regionArea><wicri:noRegion>Tasmania</wicri:noRegion></affiliation></author><author><name sortKey="Hebbring, Scott J" sort="Hebbring, Scott J" uniqKey="Hebbring S" first="Scott J." last="Hebbring">Scott J. Hebbring</name><affiliation wicri:level="2"><nlm:aff id="A7">Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, WI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, WI</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author><author><name sortKey="Wen, Cindy" sort="Wen, Cindy" uniqKey="Wen C" first="Cindy" last="Wen">Cindy Wen</name><affiliation wicri:level="2"><nlm:aff id="A8">Department of Ophthalmology, University of California San Diego and VA San Diego Health System, La Jolla, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, University of California San Diego and VA San Diego Health System, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Gorski, Mathias" sort="Gorski, Mathias" uniqKey="Gorski M" first="Mathias" last="Gorski">Mathias Gorski</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Genetic Epidemiology, University of Regensburg, Regensburg</wicri:regionArea><wicri:noRegion>Regensburg</wicri:noRegion><wicri:noRegion>Regensburg</wicri:noRegion><wicri:noRegion>Regensburg</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Ivana K" sort="Kim, Ivana K" uniqKey="Kim I" first="Ivana K." last="Kim">Ivana K. Kim</name><affiliation wicri:level="2"><nlm:aff id="A9">Retina Service, Massachusetts Eye and Ear, Department of Ophthalmology Harvard Medical School, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Retina Service, Massachusetts Eye and Ear, Department of Ophthalmology Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Cho, David" sort="Cho, David" uniqKey="Cho D" first="David" last="Cho">David Cho</name><affiliation wicri:level="2"><nlm:aff id="A10">Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Zack, Donald" sort="Zack, Donald" uniqKey="Zack D" first="Donald" last="Zack">Donald Zack</name><affiliation wicri:level="2"><nlm:aff id="A11">Department of Ophthalmology, Wilmer Eye Institute - Johns Hopkins University School of Medicine, Baltimore, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, Wilmer Eye Institute - Johns Hopkins University School of Medicine, Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A12">Department of Molecular Biology and Genetics - Johns Hopkins University School of Medicine, Baltimore, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Biology and Genetics - Johns Hopkins University School of Medicine, Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A13">Department of Neuroscience - Johns Hopkins University School of Medicine, Baltimore, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience - Johns Hopkins University School of Medicine, Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A14">Institute of Genetic Medicine - Johns Hopkins University School of Medicine, Baltimore, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute of Genetic Medicine - Johns Hopkins University School of Medicine, Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A15">Institue de la Vision, Université Pierre et Marie Curie, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institue de la Vision, Université Pierre et Marie Curie, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Pierre-et-Marie-Curie</orgName></affiliation></author><author><name sortKey="Souied, Eric" sort="Souied, Eric" uniqKey="Souied E" first="Eric" last="Souied">Eric Souied</name><affiliation wicri:level="1"><nlm:aff id="A16">Hôpital Intercommunal de Créteil, Hôpital Henri Mondor - Université Paris Est Créteil, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Hôpital Intercommunal de Créteil, Hôpital Henri Mondor - Université Paris Est Créteil</wicri:regionArea><wicri:noRegion>Hôpital Henri Mondor - Université Paris Est Créteil</wicri:noRegion><wicri:noRegion>Hôpital Henri Mondor - Université Paris Est Créteil</wicri:noRegion></affiliation></author><author><name sortKey="Scholl, Hendrik P N" sort="Scholl, Hendrik P N" uniqKey="Scholl H" first="Hendrik P. N." last="Scholl">Hendrik P. N. Scholl</name><affiliation wicri:level="2"><nlm:aff id="A11">Department of Ophthalmology, Wilmer Eye Institute - Johns Hopkins University School of Medicine, Baltimore, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, Wilmer Eye Institute - Johns Hopkins University School of Medicine, Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A17">University of Bonn - Department of Ophthalmology, Bonn, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Bonn - Department of Ophthalmology, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Bala, Elisa" sort="Bala, Elisa" uniqKey="Bala E" first="Elisa" last="Bala">Elisa Bala</name><affiliation wicri:level="2"><nlm:aff id="A18">Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Louis Stokes Cleveland VA Medical Center, Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Lee, Kristine E" sort="Lee, Kristine E" uniqKey="Lee K" first="Kristine E." last="Lee">Kristine E. Lee</name><affiliation wicri:level="2"><nlm:aff id="A19">Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name><affiliation wicri:level="2"><nlm:aff id="A20">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A21">Department of Nutrition, Harvard School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, Harvard School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Sardell, Rebecca J" sort="Sardell, Rebecca J" uniqKey="Sardell R" first="Rebecca J." last="Sardell">Rebecca J. Sardell</name><affiliation wicri:level="2"><nlm:aff id="A22">John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Mitchell, Paul" sort="Mitchell, Paul" uniqKey="Mitchell P" first="Paul" last="Mitchell">Paul Mitchell</name><affiliation wicri:level="4"><nlm:aff id="A23">Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute for Medical Research, University of Sydney, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute for Medical Research, University of Sydney, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Merriam, Joanna E" sort="Merriam, Joanna E" uniqKey="Merriam J" first="Joanna E." last="Merriam">Joanna E. Merriam</name><affiliation wicri:level="2"><nlm:aff id="A24">Department of Ophthalmology Columbia University, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology Columbia University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Cipriani, Valentina" sort="Cipriani, Valentina" uniqKey="Cipriani V" first="Valentina" last="Cipriani">Valentina Cipriani</name><affiliation wicri:level="4"><nlm:aff id="A25">UCL Institute of Ophthalmology, University College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>UCL Institute of Ophthalmology, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="A26">Moorfields Eye Hospital, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Moorfields Eye Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Hoffman, Joshua D" sort="Hoffman, Joshua D" uniqKey="Hoffman J" first="Joshua D." last="Hoffman">Joshua D. Hoffman</name><affiliation wicri:level="2"><nlm:aff id="A27">Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Schick, Tina" sort="Schick, Tina" uniqKey="Schick T" first="Tina" last="Schick">Tina Schick</name><affiliation wicri:level="1"><nlm:aff id="A28">University Hospital of Cologne, Department of Ophthalmology, Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Hospital of Cologne, Department of Ophthalmology, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Lechanteur, Yara T E" sort="Lechanteur, Yara T E" uniqKey="Lechanteur Y" first="Yara T. E." last="Lechanteur">Yara T. E. Lechanteur</name><affiliation wicri:level="3"><nlm:aff id="A29">Department of Ophthalmology, Radboud University Medical Centre, Nijmegen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, Radboud University Medical Centre, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Guymer, Robyn H" sort="Guymer, Robyn H" uniqKey="Guymer R" first="Robyn H." last="Guymer">Robyn H. Guymer</name><affiliation wicri:level="4"><nlm:aff id="A30">Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Johnson, Matthew P" sort="Johnson, Matthew P" uniqKey="Johnson M" first="Matthew P." last="Johnson">Matthew P. Johnson</name><affiliation wicri:level="2"><nlm:aff id="A31">South Texas Diabetes and Obesity Institute, School of Medicine, The University of Texas Rio Grande Valley, Brownsville, TX, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>South Texas Diabetes and Obesity Institute, School of Medicine, The University of Texas Rio Grande Valley, Brownsville, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Jiang, Yingda" sort="Jiang, Yingda" uniqKey="Jiang Y" first="Yingda" last="Jiang">Yingda Jiang</name><affiliation wicri:level="4"><nlm:aff id="A32">Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Stanton, Chloe M" sort="Stanton, Chloe M" uniqKey="Stanton C" first="Chloe M." last="Stanton">Chloe M. Stanton</name><affiliation wicri:level="4"><nlm:aff id="A33">MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Scotland, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Scotland</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Buitendijk, Gabrielle H S" sort="Buitendijk, Gabrielle H S" uniqKey="Buitendijk G" first="Gabriëlle H. S." last="Buitendijk">Gabriëlle H. S. Buitendijk</name><affiliation wicri:level="3"><nlm:aff id="A34">Department of Ophthalmology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A35">Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Zhan, Xiaowei" sort="Zhan, Xiaowei" uniqKey="Zhan X" first="Xiaowei" last="Zhan">Xiaowei Zhan</name><affiliation wicri:level="2"><nlm:aff id="A1">Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A36">Quantitative Biomedical Research Center, Department of Clinical Science, University of Texas Southwestern Medical Center, Dallas, TX, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Quantitative Biomedical Research Center, Department of Clinical Science, University of Texas Southwestern Medical Center, Dallas, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A37">Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Kwong, Alan M" sort="Kwong, Alan M" uniqKey="Kwong A" first="Alan M." last="Kwong">Alan M. Kwong</name><affiliation wicri:level="2"><nlm:aff id="A1">Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Boleda, Alexis" sort="Boleda, Alexis" uniqKey="Boleda A" first="Alexis" last="Boleda">Alexis Boleda</name><affiliation wicri:level="2"><nlm:aff id="A38">Neurobiology Neurodegeneration & Repair Laboratory (N-NRL), National Eye Institute, National Institutes of Health, Bethesda, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Neurobiology Neurodegeneration & Repair Laboratory (N-NRL), National Eye Institute, National Institutes of Health, Bethesda, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Brooks, Matthew" sort="Brooks, Matthew" uniqKey="Brooks M" first="Matthew" last="Brooks">Matthew Brooks</name><affiliation wicri:level="2"><nlm:aff id="A39">Department of Ophthalmology and Visual Sciences, University of Michigan, Kellogg Eye Center, Ann Arbor, MI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, University of Michigan, Kellogg Eye Center, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Gieser, Linn" sort="Gieser, Linn" uniqKey="Gieser L" first="Linn" last="Gieser">Linn Gieser</name><affiliation wicri:level="2"><nlm:aff id="A38">Neurobiology Neurodegeneration & Repair Laboratory (N-NRL), National Eye Institute, National Institutes of Health, Bethesda, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Neurobiology Neurodegeneration & Repair Laboratory (N-NRL), National Eye Institute, National Institutes of Health, Bethesda, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Ratnapriya, Rinki" sort="Ratnapriya, Rinki" uniqKey="Ratnapriya R" first="Rinki" last="Ratnapriya">Rinki Ratnapriya</name><affiliation wicri:level="2"><nlm:aff id="A38">Neurobiology Neurodegeneration & Repair Laboratory (N-NRL), National Eye Institute, National Institutes of Health, Bethesda, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Neurobiology Neurodegeneration & Repair Laboratory (N-NRL), National Eye Institute, National Institutes of Health, Bethesda, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Branham, Kari E" sort="Branham, Kari E" uniqKey="Branham K" first="Kari E." last="Branham">Kari E. Branham</name><affiliation wicri:level="2"><nlm:aff id="A39">Department of Ophthalmology and Visual Sciences, University of Michigan, Kellogg Eye Center, Ann Arbor, MI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, University of Michigan, Kellogg Eye Center, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Foerster, Johanna R" sort="Foerster, Johanna R" uniqKey="Foerster J" first="Johanna R." last="Foerster">Johanna R. Foerster</name><affiliation wicri:level="2"><nlm:aff id="A1">Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Heckenlively, John R" sort="Heckenlively, John R" uniqKey="Heckenlively J" first="John R." last="Heckenlively">John R. Heckenlively</name><affiliation wicri:level="2"><nlm:aff id="A39">Department of Ophthalmology and Visual Sciences, University of Michigan, Kellogg Eye Center, Ann Arbor, MI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, University of Michigan, Kellogg Eye Center, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Othman, Mohammad I" sort="Othman, Mohammad I" uniqKey="Othman M" first="Mohammad I." last="Othman">Mohammad I. Othman</name><affiliation wicri:level="2"><nlm:aff id="A39">Department of Ophthalmology and Visual Sciences, University of Michigan, Kellogg Eye Center, Ann Arbor, MI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, University of Michigan, Kellogg Eye Center, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Vote, Brendan J" sort="Vote, Brendan J" uniqKey="Vote B" first="Brendan J." last="Vote">Brendan J. Vote</name><affiliation wicri:level="1"><nlm:aff id="A6">School of Medicine, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>School of Medicine, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania</wicri:regionArea><wicri:noRegion>Tasmania</wicri:noRegion></affiliation></author><author><name sortKey="Liang, Helena Hai" sort="Liang, Helena Hai" uniqKey="Liang H" first="Helena Hai" last="Liang">Helena Hai Liang</name><affiliation wicri:level="4"><nlm:aff id="A30">Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Souzeau, Emmanuelle" sort="Souzeau, Emmanuelle" uniqKey="Souzeau E" first="Emmanuelle" last="Souzeau">Emmanuelle Souzeau</name><affiliation wicri:level="1"><nlm:aff id="A40">Department of Ophthalmology, Flinders Medical Centre, Flinders University, Adelaide, South Australia, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Ophthalmology, Flinders Medical Centre, Flinders University, Adelaide, South Australia</wicri:regionArea><wicri:noRegion>South Australia</wicri:noRegion></affiliation></author><author><name sortKey="Mcallister, Ian L" sort="Mcallister, Ian L" uniqKey="Mcallister I" first="Ian L." last="Mcallister">Ian L. Mcallister</name><affiliation wicri:level="1"><nlm:aff id="A41">Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Western Australia, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Western Australia</wicri:regionArea><wicri:noRegion>Western Australia</wicri:noRegion></affiliation></author><author><name sortKey="Isaacs, Timothy" sort="Isaacs, Timothy" uniqKey="Isaacs T" first="Timothy" last="Isaacs">Timothy Isaacs</name><affiliation wicri:level="1"><nlm:aff id="A41">Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Western Australia, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Western Australia</wicri:regionArea><wicri:noRegion>Western Australia</wicri:noRegion></affiliation></author><author><name sortKey="Hall, Janette" sort="Hall, Janette" uniqKey="Hall J" first="Janette" last="Hall">Janette Hall</name><affiliation wicri:level="1"><nlm:aff id="A40">Department of Ophthalmology, Flinders Medical Centre, Flinders University, Adelaide, South Australia, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Ophthalmology, Flinders Medical Centre, Flinders University, Adelaide, South Australia</wicri:regionArea><wicri:noRegion>South Australia</wicri:noRegion></affiliation></author><author><name sortKey="Lake, Stewart" sort="Lake, Stewart" uniqKey="Lake S" first="Stewart" last="Lake">Stewart Lake</name><affiliation wicri:level="1"><nlm:aff id="A40">Department of Ophthalmology, Flinders Medical Centre, Flinders University, Adelaide, South Australia, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Ophthalmology, Flinders Medical Centre, Flinders University, Adelaide, South Australia</wicri:regionArea><wicri:noRegion>South Australia</wicri:noRegion></affiliation></author><author><name sortKey="Mackey, David A" sort="Mackey, David A" uniqKey="Mackey D" first="David A." last="Mackey">David A. Mackey</name><affiliation wicri:level="1"><nlm:aff id="A6">School of Medicine, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>School of Medicine, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania</wicri:regionArea><wicri:noRegion>Tasmania</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A30">Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A41">Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Western Australia, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Western Australia</wicri:regionArea><wicri:noRegion>Western Australia</wicri:noRegion></affiliation></author><author><name sortKey="Constable, Ian J" sort="Constable, Ian J" uniqKey="Constable I" first="Ian J." last="Constable">Ian J. Constable</name><affiliation wicri:level="1"><nlm:aff id="A41">Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Western Australia, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Western Australia</wicri:regionArea><wicri:noRegion>Western Australia</wicri:noRegion></affiliation></author><author><name sortKey="Craig, Jamie E" sort="Craig, Jamie E" uniqKey="Craig J" first="Jamie E." last="Craig">Jamie E. Craig</name><affiliation wicri:level="1"><nlm:aff id="A40">Department of Ophthalmology, Flinders Medical Centre, Flinders University, Adelaide, South Australia, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Ophthalmology, Flinders Medical Centre, Flinders University, Adelaide, South Australia</wicri:regionArea><wicri:noRegion>South Australia</wicri:noRegion></affiliation></author><author><name sortKey="Kitchner, Terrie E" sort="Kitchner, Terrie E" uniqKey="Kitchner T" first="Terrie E." last="Kitchner">Terrie E. Kitchner</name><affiliation wicri:level="2"><nlm:aff id="A7">Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, WI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, WI</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author><author><name sortKey="Yang, Zhenglin" sort="Yang, Zhenglin" uniqKey="Yang Z" first="Zhenglin" last="Yang">Zhenglin Yang</name><affiliation wicri:level="1"><nlm:aff id="A42">Sichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Sichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu</wicri:regionArea><wicri:noRegion>Chengdu</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A43">Sichuan Translational Medicine Hospital, Chinese Academy of Sciences, Chengdu, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Sichuan Translational Medicine Hospital, Chinese Academy of Sciences, Chengdu</wicri:regionArea><wicri:noRegion>Chengdu</wicri:noRegion></affiliation></author><author><name sortKey="Su, Zhiguang" sort="Su, Zhiguang" uniqKey="Su Z" first="Zhiguang" last="Su">Zhiguang Su</name><affiliation wicri:level="1"><nlm:aff id="A44">Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan</wicri:regionArea><wicri:noRegion>Sichuan</wicri:noRegion></affiliation></author><author><name sortKey="Luo, Hongrong" sort="Luo, Hongrong" uniqKey="Luo H" first="Hongrong" last="Luo">Hongrong Luo</name><affiliation wicri:level="2"><nlm:aff id="A8">Department of Ophthalmology, University of California San Diego and VA San Diego Health System, La Jolla, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, University of California San Diego and VA San Diego Health System, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A44">Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan</wicri:regionArea><wicri:noRegion>Sichuan</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Daniel" sort="Chen, Daniel" uniqKey="Chen D" first="Daniel" last="Chen">Daniel Chen</name><affiliation wicri:level="2"><nlm:aff id="A8">Department of Ophthalmology, University of California San Diego and VA San Diego Health System, La Jolla, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, University of California San Diego and VA San Diego Health System, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Ouyang, Hong" sort="Ouyang, Hong" uniqKey="Ouyang H" first="Hong" last="Ouyang">Hong Ouyang</name><affiliation wicri:level="2"><nlm:aff id="A8">Department of Ophthalmology, University of California San Diego and VA San Diego Health System, La Jolla, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, University of California San Diego and VA San Diego Health System, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Flagg, Ken" sort="Flagg, Ken" uniqKey="Flagg K" first="Ken" last="Flagg">Ken Flagg</name><affiliation wicri:level="2"><nlm:aff id="A8">Department of Ophthalmology, University of California San Diego and VA San Diego Health System, La Jolla, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, University of California San Diego and VA San Diego Health System, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Lin, Danni" sort="Lin, Danni" uniqKey="Lin D" first="Danni" last="Lin">Danni Lin</name><affiliation wicri:level="2"><nlm:aff id="A8">Department of Ophthalmology, University of California San Diego and VA San Diego Health System, La Jolla, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, University of California San Diego and VA San Diego Health System, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Mao, Guanping" sort="Mao, Guanping" uniqKey="Mao G" first="Guanping" last="Mao">Guanping Mao</name><affiliation wicri:level="2"><nlm:aff id="A8">Department of Ophthalmology, University of California San Diego and VA San Diego Health System, La Jolla, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, University of California San Diego and VA San Diego Health System, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Ferreyra, Henry" sort="Ferreyra, Henry" uniqKey="Ferreyra H" first="Henry" last="Ferreyra">Henry Ferreyra</name><affiliation wicri:level="2"><nlm:aff id="A8">Department of Ophthalmology, University of California San Diego and VA San Diego Health System, La Jolla, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, University of California San Diego and VA San Diego Health System, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Stark, Klaus" sort="Stark, Klaus" uniqKey="Stark K" first="Klaus" last="Stark">Klaus Stark</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Genetic Epidemiology, University of Regensburg, Regensburg</wicri:regionArea><wicri:noRegion>Regensburg</wicri:noRegion><wicri:noRegion>Regensburg</wicri:noRegion><wicri:noRegion>Regensburg</wicri:noRegion></affiliation></author><author><name sortKey="Von Strachwitz, Claudia N" sort="Von Strachwitz, Claudia N" uniqKey="Von Strachwitz C" first="Claudia N." last="Von Strachwitz">Claudia N. Von Strachwitz</name><affiliation wicri:level="1"><nlm:aff id="A45">EyeCentre Southwest, Stuttgart, Baden-Württemberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>EyeCentre Southwest, Stuttgart, Baden-Württemberg</wicri:regionArea><wicri:noRegion>Baden-Württemberg</wicri:noRegion><wicri:noRegion>Baden-Württemberg</wicri:noRegion><wicri:noRegion>Baden-Württemberg</wicri:noRegion></affiliation></author><author><name sortKey="Wolf, Armin" sort="Wolf, Armin" uniqKey="Wolf A" first="Armin" last="Wolf">Armin Wolf</name><affiliation wicri:level="3"><nlm:aff id="A46">University Eye Clinic, Ludwig-Maximilians-University, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Eye Clinic, Ludwig-Maximilians-University, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Brandl, Caroline" sort="Brandl, Caroline" uniqKey="Brandl C" first="Caroline" last="Brandl">Caroline Brandl</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Genetic Epidemiology, University of Regensburg, Regensburg</wicri:regionArea><wicri:noRegion>Regensburg</wicri:noRegion><wicri:noRegion>Regensburg</wicri:noRegion><wicri:noRegion>Regensburg</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">Institute of Human Genetics, University of Regensburg, Regensburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Human Genetics, University of Regensburg, Regensburg</wicri:regionArea><wicri:noRegion>Regensburg</wicri:noRegion><wicri:noRegion>Regensburg</wicri:noRegion><wicri:noRegion>Regensburg</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A47">Department of Ophthalmology, University Hospital Regensburg, Regensburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Ophthalmology, University Hospital Regensburg, Regensburg</wicri:regionArea><wicri:noRegion>Regensburg</wicri:noRegion><wicri:noRegion>Regensburg</wicri:noRegion><wicri:noRegion>Regensburg</wicri:noRegion></affiliation></author><author><name sortKey="Rudolph, Guenther" sort="Rudolph, Guenther" uniqKey="Rudolph G" first="Guenther" last="Rudolph">Guenther Rudolph</name><affiliation wicri:level="3"><nlm:aff id="A46">University Eye Clinic, Ludwig-Maximilians-University, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Eye Clinic, Ludwig-Maximilians-University, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Olden, Matthias" sort="Olden, Matthias" uniqKey="Olden M" first="Matthias" last="Olden">Matthias Olden</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Genetic Epidemiology, University of Regensburg, Regensburg</wicri:regionArea><wicri:noRegion>Regensburg</wicri:noRegion><wicri:noRegion>Regensburg</wicri:noRegion><wicri:noRegion>Regensburg</wicri:noRegion></affiliation></author><author><name sortKey="Morrison, Margaux A" sort="Morrison, Margaux A" uniqKey="Morrison M" first="Margaux A." last="Morrison">Margaux A. Morrison</name><affiliation wicri:level="2"><nlm:aff id="A48">Department of Ophthalmology and Visual Sciences, University of Utah, Salt Lake City, UT, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, University of Utah, Salt Lake City, UT</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="Morgan, Denise J" sort="Morgan, Denise J" uniqKey="Morgan D" first="Denise J." last="Morgan">Denise J. Morgan</name><affiliation wicri:level="2"><nlm:aff id="A48">Department of Ophthalmology and Visual Sciences, University of Utah, Salt Lake City, UT, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, University of Utah, Salt Lake City, UT</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="Schu, Matthew" sort="Schu, Matthew" uniqKey="Schu M" first="Matthew" last="Schu">Matthew Schu</name><affiliation wicri:level="2"><nlm:aff id="A49">Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine and Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine and Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A50">Department of Ophthalmology, Boston University Schools of Medicine and Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, Boston University Schools of Medicine and Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A51">Department of Neurology, Boston University Schools of Medicine and Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Boston University Schools of Medicine and Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A52">Department of Epidemiology, Boston University Schools of Medicine and Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Boston University Schools of Medicine and Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A53">Department of Biostatistics, Boston University Schools of Medicine and Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Boston University Schools of Medicine and Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Ahn, Jeeyun" sort="Ahn, Jeeyun" uniqKey="Ahn J" first="Jeeyun" last="Ahn">Jeeyun Ahn</name><affiliation wicri:level="3"><nlm:aff id="A54">Department of Ophthalmology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Ophthalmology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Silvestri, Giuliana" sort="Silvestri, Giuliana" uniqKey="Silvestri G" first="Giuliana" last="Silvestri">Giuliana Silvestri</name><affiliation wicri:level="1"><nlm:aff id="A55">Centre for Experimental Medicine, Queen's University, Belfast, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Experimental Medicine, Queen's University, Belfast</wicri:regionArea><wicri:noRegion>Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Tsironi, Evangelia E" sort="Tsironi, Evangelia E" uniqKey="Tsironi E" first="Evangelia E." last="Tsironi">Evangelia E. Tsironi</name><affiliation wicri:level="1"><nlm:aff id="A56">Department of Ophthalmology, University of Thessaly, School of Medicine, Larissa, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Ophthalmology, University of Thessaly, School of Medicine, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation></author><author><name sortKey="Park, Kyu Hyung" sort="Park, Kyu Hyung" uniqKey="Park K" first="Kyu Hyung" last="Park">Kyu Hyung Park</name><affiliation wicri:level="1"><nlm:aff id="A57">Department of Ophthalmology, Seoul National University Bundang Hospital, Seongnam, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Ophthalmology, Seoul National University Bundang Hospital, Seongnam</wicri:regionArea><wicri:noRegion>Seongnam</wicri:noRegion></affiliation></author><author><name sortKey="Farrer, Lindsay A" sort="Farrer, Lindsay A" uniqKey="Farrer L" first="Lindsay A." last="Farrer">Lindsay A. Farrer</name><affiliation wicri:level="2"><nlm:aff id="A49">Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine and Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine and Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A50">Department of Ophthalmology, Boston University Schools of Medicine and Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, Boston University Schools of Medicine and Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A51">Department of Neurology, Boston University Schools of Medicine and Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Boston University Schools of Medicine and Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A52">Department of Epidemiology, Boston University Schools of Medicine and Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Boston University Schools of Medicine and Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A53">Department of Biostatistics, Boston University Schools of Medicine and Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Boston University Schools of Medicine and Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Orlin, Anton" sort="Orlin, Anton" uniqKey="Orlin A" first="Anton" last="Orlin">Anton Orlin</name><affiliation wicri:level="2"><nlm:aff id="A58">Department of Ophthalmology, Weill Cornell Medical College, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, Weill Cornell Medical College, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Brucker, Alexander" sort="Brucker, Alexander" uniqKey="Brucker A" first="Alexander" last="Brucker">Alexander Brucker</name><affiliation wicri:level="2"><nlm:aff id="A59">Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Li, Mingyao" sort="Li, Mingyao" uniqKey="Li M" first="Mingyao" last="Li">Mingyao Li</name><affiliation wicri:level="2"><nlm:aff id="A60">Department of Biostatistics and Epidemiology University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics and Epidemiology University of Pennsylvania Perelman School of Medicine, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Curcio, Christine" sort="Curcio, Christine" uniqKey="Curcio C" first="Christine" last="Curcio">Christine Curcio</name><affiliation wicri:level="2"><nlm:aff id="A61">Department of Ophthalmology, The University of Alabama at Birmingham, Birmingham, AL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, The University of Alabama at Birmingham, Birmingham, AL</wicri:regionArea><placeName><region type="state">Alabama</region></placeName></affiliation></author><author><name sortKey="Mohand Said, Saddek" sort="Mohand Said, Saddek" uniqKey="Mohand Said S" first="Saddek" last="Mohand-Saïd">Saddek Mohand-Saïd</name><affiliation wicri:level="3"><nlm:aff id="A62">INSERM, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A63">Institut de la Vision, Department of Genetics, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut de la Vision, Department of Genetics, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A64">CNRS, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A65">Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Sahel, Jose Alain" sort="Sahel, Jose Alain" uniqKey="Sahel J" first="José-Alain" last="Sahel">José-Alain Sahel</name><affiliation wicri:level="4"><nlm:aff id="A25">UCL Institute of Ophthalmology, University College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>UCL Institute of Ophthalmology, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="A62">INSERM, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A63">Institut de la Vision, Department of Genetics, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut de la Vision, Department of Genetics, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A64">CNRS, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A65">Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A66">Fondation Ophtalmologique Adolphe de Rothschild, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Fondation Ophtalmologique Adolphe de Rothschild, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A67">Académie des Sciences–Institut de France, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Académie des Sciences–Institut de France, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Audo, Isabelle" sort="Audo, Isabelle" uniqKey="Audo I" first="Isabelle" last="Audo">Isabelle Audo</name><affiliation wicri:level="3"><nlm:aff id="A62">INSERM, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A63">Institut de la Vision, Department of Genetics, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut de la Vision, Department of Genetics, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A64">CNRS, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A68">Department of Molecular Genetics, Institute of Ophthalmology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Molecular Genetics, Institute of Ophthalmology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Benchaboune, Mustapha" sort="Benchaboune, Mustapha" uniqKey="Benchaboune M" first="Mustapha" last="Benchaboune">Mustapha Benchaboune</name><affiliation wicri:level="3"><nlm:aff id="A65">Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Cree, Angela J" sort="Cree, Angela J" uniqKey="Cree A" first="Angela J." last="Cree">Angela J. Cree</name><affiliation wicri:level="1"><nlm:aff id="A69">Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton</wicri:regionArea><wicri:noRegion>University of Southampton</wicri:noRegion></affiliation></author><author><name sortKey="Rennie, Christina A" sort="Rennie, Christina A" uniqKey="Rennie C" first="Christina A." last="Rennie">Christina A. Rennie</name><affiliation wicri:level="1"><nlm:aff id="A70">University Hospital Southampton, Southampton, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University Hospital Southampton, Southampton</wicri:regionArea><wicri:noRegion>Southampton</wicri:noRegion></affiliation></author><author><name sortKey="Goverdhan, Srinivas V" sort="Goverdhan, Srinivas V" uniqKey="Goverdhan S" first="Srinivas V." last="Goverdhan">Srinivas V. Goverdhan</name><affiliation wicri:level="1"><nlm:aff id="A69">Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton</wicri:regionArea><wicri:noRegion>University of Southampton</wicri:noRegion></affiliation></author><author><name sortKey="Grunin, Michelle" sort="Grunin, Michelle" uniqKey="Grunin M" first="Michelle" last="Grunin">Michelle Grunin</name><affiliation wicri:level="1"><nlm:aff id="A71">Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem</wicri:regionArea><wicri:noRegion>Jerusalem</wicri:noRegion></affiliation></author><author><name sortKey="Hagbi Levi, Shira" sort="Hagbi Levi, Shira" uniqKey="Hagbi Levi S" first="Shira" last="Hagbi-Levi">Shira Hagbi-Levi</name><affiliation wicri:level="1"><nlm:aff id="A71">Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem</wicri:regionArea><wicri:noRegion>Jerusalem</wicri:noRegion></affiliation></author><author><name sortKey="Campochiaro, Peter" sort="Campochiaro, Peter" uniqKey="Campochiaro P" first="Peter" last="Campochiaro">Peter Campochiaro</name><affiliation wicri:level="2"><nlm:aff id="A11">Department of Ophthalmology, Wilmer Eye Institute - Johns Hopkins University School of Medicine, Baltimore, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, Wilmer Eye Institute - Johns Hopkins University School of Medicine, Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A13">Department of Neuroscience - Johns Hopkins University School of Medicine, Baltimore, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience - Johns Hopkins University School of Medicine, Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Katsanis, Nicholas" sort="Katsanis, Nicholas" uniqKey="Katsanis N" first="Nicholas" last="Katsanis">Nicholas Katsanis</name><affiliation wicri:level="2"><nlm:aff id="A72">Center for Human Disease Modeling, Duke University, Durham, NC, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Human Disease Modeling, Duke University, Durham, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A73">Department of Cell Biology, Duke University, Durham, NC, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cell Biology, Duke University, Durham, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A74">Department of Pediatrics, Duke University, Durham, NC, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, Duke University, Durham, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Holz, Frank G" sort="Holz, Frank G" uniqKey="Holz F" first="Frank G." last="Holz">Frank G. Holz</name><affiliation wicri:level="3"><nlm:aff id="A17">University of Bonn - Department of Ophthalmology, Bonn, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Bonn - Department of Ophthalmology, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Blond, Frederic" sort="Blond, Frederic" uniqKey="Blond F" first="Frédéric" last="Blond">Frédéric Blond</name><affiliation wicri:level="3"><nlm:aff id="A62">INSERM, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A63">Institut de la Vision, Department of Genetics, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut de la Vision, Department of Genetics, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A64">CNRS, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Blanche, Helene" sort="Blanche, Helene" uniqKey="Blanche H" first="Hélène" last="Blanché">Hélène Blanché</name><affiliation wicri:level="1"><nlm:aff id="A75">CEPH Fondation Jean Dausset Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CEPH Fondation Jean Dausset Paris</wicri:regionArea></affiliation></author><author><name sortKey="Deleuze, Jean Francois" sort="Deleuze, Jean Francois" uniqKey="Deleuze J" first="Jean-François" last="Deleuze">Jean-François Deleuze</name><affiliation wicri:level="1"><nlm:aff id="A75">CEPH Fondation Jean Dausset Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CEPH Fondation Jean Dausset Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A76">CEA – IG – Centre National de Génotypage Evry Cédex, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CEA – IG – Centre National de Génotypage Evry Cédex</wicri:regionArea></affiliation></author><author><name sortKey="Igo, Robert P" sort="Igo, Robert P" uniqKey="Igo R" first="Robert P." last="Igo">Robert P. Igo</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Truitt, Barbara" sort="Truitt, Barbara" uniqKey="Truitt B" first="Barbara" last="Truitt">Barbara Truitt</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Peachey, Neal S" sort="Peachey, Neal S" uniqKey="Peachey N" first="Neal S." last="Peachey">Neal S. Peachey</name><affiliation wicri:level="2"><nlm:aff id="A18">Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Louis Stokes Cleveland VA Medical Center, Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A77">Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cole Eye Institute, Cleveland Clinic, Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Meuer, Stacy M" sort="Meuer, Stacy M" uniqKey="Meuer S" first="Stacy M." last="Meuer">Stacy M. Meuer</name><affiliation wicri:level="2"><nlm:aff id="A19">Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author><author><name sortKey="Myers, Chelsea E" sort="Myers, Chelsea E" uniqKey="Myers C" first="Chelsea E." last="Myers">Chelsea E. Myers</name><affiliation wicri:level="2"><nlm:aff id="A19">Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author><author><name sortKey="Moore, Emily L" sort="Moore, Emily L" uniqKey="Moore E" first="Emily L." last="Moore">Emily L. Moore</name><affiliation wicri:level="2"><nlm:aff id="A19">Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author><author><name sortKey="Klein, Ronald" sort="Klein, Ronald" uniqKey="Klein R" first="Ronald" last="Klein">Ronald Klein</name><affiliation wicri:level="2"><nlm:aff id="A19">Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author><author><name sortKey="Hauser, Michael A" sort="Hauser, Michael A" uniqKey="Hauser M" first="Michael A." last="Hauser">Michael A. Hauser</name><affiliation wicri:level="2"><nlm:aff id="A78">Department of Ophthalmology, Duke University Medical Center, Durham, NC, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, Duke University Medical Center, Durham, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A79">Department of Medicine, Duke University Medical Center, Durham, NC, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Duke University Medical Center, Durham, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A80">Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Postel, Eric A" sort="Postel, Eric A" uniqKey="Postel E" first="Eric A." last="Postel">Eric A. Postel</name><affiliation wicri:level="2"><nlm:aff id="A78">Department of Ophthalmology, Duke University Medical Center, Durham, NC, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, Duke University Medical Center, Durham, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Courtenay, Monique D" sort="Courtenay, Monique D" uniqKey="Courtenay M" first="Monique D." last="Courtenay">Monique D. Courtenay</name><affiliation wicri:level="2"><nlm:aff id="A22">John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Schwartz, Stephen G" sort="Schwartz, Stephen G" uniqKey="Schwartz S" first="Stephen G." last="Schwartz">Stephen G. Schwartz</name><affiliation wicri:level="2"><nlm:aff id="A81">Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Naples, FL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Naples, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Kovach, Jaclyn L" sort="Kovach, Jaclyn L" uniqKey="Kovach J" first="Jaclyn L." last="Kovach">Jaclyn L. Kovach</name><affiliation wicri:level="2"><nlm:aff id="A81">Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Naples, FL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Naples, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Scott, William K" sort="Scott, William K" uniqKey="Scott W" first="William K." last="Scott">William K. Scott</name><affiliation wicri:level="2"><nlm:aff id="A22">John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Liew, Gerald" sort="Liew, Gerald" uniqKey="Liew G" first="Gerald" last="Liew">Gerald Liew</name><affiliation wicri:level="4"><nlm:aff id="A23">Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute for Medical Research, University of Sydney, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute for Medical Research, University of Sydney, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="T An, Ava G" sort="T An, Ava G" uniqKey="T An A" first="Ava G." last="T An">Ava G. T An</name><affiliation wicri:level="4"><nlm:aff id="A23">Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute for Medical Research, University of Sydney, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute for Medical Research, University of Sydney, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Gopinath, Bamini" sort="Gopinath, Bamini" uniqKey="Gopinath B" first="Bamini" last="Gopinath">Bamini Gopinath</name><affiliation wicri:level="4"><nlm:aff id="A23">Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute for Medical Research, University of Sydney, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute for Medical Research, University of Sydney, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Merriam, John C" sort="Merriam, John C" uniqKey="Merriam J" first="John C." last="Merriam">John C. Merriam</name><affiliation wicri:level="2"><nlm:aff id="A24">Department of Ophthalmology Columbia University, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology Columbia University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Smith, R Theodore" sort="Smith, R Theodore" uniqKey="Smith R" first="R. Theodore" last="Smith">R. Theodore Smith</name><affiliation wicri:level="2"><nlm:aff id="A24">Department of Ophthalmology Columbia University, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology Columbia University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A82">Department of Ophthalmology, NYU School of Medicine, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, NYU School of Medicine, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Khan, Jane C" sort="Khan, Jane C" uniqKey="Khan J" first="Jane C." last="Khan">Jane C. Khan</name><affiliation wicri:level="1"><nlm:aff id="A41">Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Western Australia, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Western Australia</wicri:regionArea><wicri:noRegion>Western Australia</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A83">Department of Ophthalmology, Royal Perth Hospital, Perth, Western Australia, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Ophthalmology, Royal Perth Hospital, Perth, Western Australia</wicri:regionArea><wicri:noRegion>Western Australia</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A84">Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Shahid, Humma" sort="Shahid, Humma" uniqKey="Shahid H" first="Humma" last="Shahid">Humma Shahid</name><affiliation wicri:level="4"><nlm:aff id="A84">Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A85">Department of Ophthalmology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Ophthalmology, Cambridge University Hospitals NHS Foundation Trust, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Moore, Anthony T" sort="Moore, Anthony T" uniqKey="Moore A" first="Anthony T." last="Moore">Anthony T. Moore</name><affiliation wicri:level="4"><nlm:aff id="A25">UCL Institute of Ophthalmology, University College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>UCL Institute of Ophthalmology, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="A26">Moorfields Eye Hospital, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Moorfields Eye Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A86">Department of Ophthalmology UCSF Medical School, San Francisco, CA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Ophthalmology UCSF Medical School, San Francisco</wicri:cityArea></affiliation></author><author><name sortKey="Mcgrath, J Allie" sort="Mcgrath, J Allie" uniqKey="Mcgrath J" first="J. Allie" last="Mcgrath">J. Allie Mcgrath</name><affiliation wicri:level="2"><nlm:aff id="A27">Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Laux, Renee" sort="Laux, Renee" uniqKey="Laux R" first="Reneé" last="Laux">Reneé Laux</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Brantley, Milam A" sort="Brantley, Milam A" uniqKey="Brantley M" first="Milam A." last="Brantley">Milam A. Brantley</name><affiliation wicri:level="2"><nlm:aff id="A87">Department of Ophthalmology and Visual Sciences, Vanderbilt University, Nashville, TN, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, Vanderbilt University, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Agarwal, Anita" sort="Agarwal, Anita" uniqKey="Agarwal A" first="Anita" last="Agarwal">Anita Agarwal</name><affiliation wicri:level="2"><nlm:aff id="A87">Department of Ophthalmology and Visual Sciences, Vanderbilt University, Nashville, TN, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, Vanderbilt University, Nashville, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Ersoy, Lebriz" sort="Ersoy, Lebriz" uniqKey="Ersoy L" first="Lebriz" last="Ersoy">Lebriz Ersoy</name><affiliation wicri:level="1"><nlm:aff id="A28">University Hospital of Cologne, Department of Ophthalmology, Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Hospital of Cologne, Department of Ophthalmology, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Caramoy, Albert" sort="Caramoy, Albert" uniqKey="Caramoy A" first="Albert" last="Caramoy">Albert Caramoy</name><affiliation wicri:level="1"><nlm:aff id="A28">University Hospital of Cologne, Department of Ophthalmology, Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Hospital of Cologne, Department of Ophthalmology, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Langmann, Thomas" sort="Langmann, Thomas" uniqKey="Langmann T" first="Thomas" last="Langmann">Thomas Langmann</name><affiliation wicri:level="1"><nlm:aff id="A28">University Hospital of Cologne, Department of Ophthalmology, Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Hospital of Cologne, Department of Ophthalmology, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Saksens, Nicole T M" sort="Saksens, Nicole T M" uniqKey="Saksens N" first="Nicole T. M." last="Saksens">Nicole T. M. Saksens</name><affiliation wicri:level="3"><nlm:aff id="A29">Department of Ophthalmology, Radboud University Medical Centre, Nijmegen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, Radboud University Medical Centre, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="De Jong, Eiko K" sort="De Jong, Eiko K" uniqKey="De Jong E" first="Eiko K." last="De Jong">Eiko K. De Jong</name><affiliation wicri:level="3"><nlm:aff id="A29">Department of Ophthalmology, Radboud University Medical Centre, Nijmegen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, Radboud University Medical Centre, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Hoyng, Carel B" sort="Hoyng, Carel B" uniqKey="Hoyng C" first="Carel B." last="Hoyng">Carel B. Hoyng</name><affiliation wicri:level="3"><nlm:aff id="A29">Department of Ophthalmology, Radboud University Medical Centre, Nijmegen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, Radboud University Medical Centre, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Cain, Melinda S" sort="Cain, Melinda S" uniqKey="Cain M" first="Melinda S." last="Cain">Melinda S. Cain</name><affiliation wicri:level="4"><nlm:aff id="A30">Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Richardson, Andrea J" sort="Richardson, Andrea J" uniqKey="Richardson A" first="Andrea J." last="Richardson">Andrea J. Richardson</name><affiliation wicri:level="4"><nlm:aff id="A30">Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Martin, Tammy M" sort="Martin, Tammy M" uniqKey="Martin T" first="Tammy M." last="Martin">Tammy M. Martin</name><affiliation wicri:level="4"><nlm:aff id="A88">Casey Eye Institute, Oregon Health & Science University, Portland OR, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Casey Eye Institute, Oregon Health & Science University, Portland OR</wicri:regionArea><orgName type="university">Université des sciences et de la médecine de l'Oregon</orgName><placeName><settlement type="city">Portland</settlement><region type="state">Oregon</region></placeName></affiliation></author><author><name sortKey="Blangero, John" sort="Blangero, John" uniqKey="Blangero J" first="John" last="Blangero">John Blangero</name><affiliation wicri:level="2"><nlm:aff id="A31">South Texas Diabetes and Obesity Institute, School of Medicine, The University of Texas Rio Grande Valley, Brownsville, TX, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>South Texas Diabetes and Obesity Institute, School of Medicine, The University of Texas Rio Grande Valley, Brownsville, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Weeks, Daniel E" sort="Weeks, Daniel E" uniqKey="Weeks D" first="Daniel E." last="Weeks">Daniel E. Weeks</name><affiliation wicri:level="4"><nlm:aff id="A32">Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A89">Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Dhillon, Bal" sort="Dhillon, Bal" uniqKey="Dhillon B" first="Bal" last="Dhillon">Bal Dhillon</name><affiliation wicri:level="4"><nlm:aff id="A90">School of Clinical Sciences University of Edinburgh, Scotland, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Clinical Sciences University of Edinburgh, Scotland</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M." last="Van Duijn">Cornelia M. Van Duijn</name><affiliation wicri:level="3"><nlm:aff id="A35">Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Doheny, Kimberly F" sort="Doheny, Kimberly F" uniqKey="Doheny K" first="Kimberly F." last="Doheny">Kimberly F. Doheny</name><affiliation wicri:level="2"><nlm:aff id="A91">Center for Inherited Disease Research (CIDR) Institute of Genetic Medicine Johns Hopkins University School of Medicine Baltimore, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Inherited Disease Research (CIDR) Institute of Genetic Medicine Johns Hopkins University School of Medicine Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Romm, Jane" sort="Romm, Jane" uniqKey="Romm J" first="Jane" last="Romm">Jane Romm</name><affiliation wicri:level="2"><nlm:aff id="A91">Center for Inherited Disease Research (CIDR) Institute of Genetic Medicine Johns Hopkins University School of Medicine Baltimore, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Inherited Disease Research (CIDR) Institute of Genetic Medicine Johns Hopkins University School of Medicine Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Klaver, Caroline C W" sort="Klaver, Caroline C W" uniqKey="Klaver C" first="Caroline C. W." last="Klaver">Caroline C. W. Klaver</name><affiliation wicri:level="3"><nlm:aff id="A34">Department of Ophthalmology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A35">Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name><affiliation wicri:level="4"><nlm:aff id="A33">MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Scotland, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Scotland</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Gorin, Michael B" sort="Gorin, Michael B" uniqKey="Gorin M" first="Michael B." last="Gorin">Michael B. Gorin</name><affiliation wicri:level="2"><nlm:aff id="A92">Department of Ophthalmology, David Geffen School of Medicine—UCLA, Stein Eye Institute, Los Angeles, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, David Geffen School of Medicine—UCLA, Stein Eye Institute, Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A93">Department of Human Genetics, David Geffen School of Medicine—UCLA, Los Angeles, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Human Genetics, David Geffen School of Medicine—UCLA, Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Klein, Michael L" sort="Klein, Michael L" uniqKey="Klein M" first="Michael L." last="Klein">Michael L. Klein</name><affiliation wicri:level="4"><nlm:aff id="A88">Casey Eye Institute, Oregon Health & Science University, Portland OR, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Casey Eye Institute, Oregon Health & Science University, Portland OR</wicri:regionArea><orgName type="university">Université des sciences et de la médecine de l'Oregon</orgName><placeName><settlement type="city">Portland</settlement><region type="state">Oregon</region></placeName></affiliation></author><author><name sortKey="Baird, Paul N" sort="Baird, Paul N" uniqKey="Baird P" first="Paul N." last="Baird">Paul N. Baird</name><affiliation wicri:level="4"><nlm:aff id="A30">Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Den Hollander, Anneke I" sort="Den Hollander, Anneke I" uniqKey="Den Hollander A" first="Anneke I." last="Den Hollander">Anneke I. Den Hollander</name><affiliation wicri:level="3"><nlm:aff id="A29">Department of Ophthalmology, Radboud University Medical Centre, Nijmegen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Ophthalmology, Radboud University Medical Centre, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A94">Department of Human Genetics, Radboud University Medical Centre, Nijmegen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Human Genetics, Radboud University Medical Centre, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Fauser, Sascha" sort="Fauser, Sascha" uniqKey="Fauser S" first="Sascha" last="Fauser">Sascha Fauser</name><affiliation wicri:level="1"><nlm:aff id="A28">University Hospital of Cologne, Department of Ophthalmology, Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Hospital of Cologne, Department of Ophthalmology, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Yates, John R W" sort="Yates, John R W" uniqKey="Yates J" first="John R. W." last="Yates">John R. W. Yates</name><affiliation wicri:level="4"><nlm:aff id="A25">UCL Institute of Ophthalmology, University College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>UCL Institute of Ophthalmology, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="A26">Moorfields Eye Hospital, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Moorfields Eye Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A84">Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Allikmets, Rando" sort="Allikmets, Rando" uniqKey="Allikmets R" first="Rando" last="Allikmets">Rando Allikmets</name><affiliation wicri:level="2"><nlm:aff id="A24">Department of Ophthalmology Columbia University, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology Columbia University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A95">Department of Pathology & Cell Biology, Columbia University, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology & Cell Biology, Columbia University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Wang, Jie Jin" sort="Wang, Jie Jin" uniqKey="Wang J" first="Jie Jin" last="Wang">Jie Jin Wang</name><affiliation wicri:level="4"><nlm:aff id="A23">Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute for Medical Research, University of Sydney, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute for Medical Research, University of Sydney, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Schaumberg, Debra A" sort="Schaumberg, Debra A" uniqKey="Schaumberg D" first="Debra A." last="Schaumberg">Debra A. Schaumberg</name><affiliation wicri:level="2"><nlm:aff id="A20">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A96">Center for Translational Medicine, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Translational Medicine, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A97">Division of Preventive Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Preventive Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Klein, Barbara E K" sort="Klein, Barbara E K" uniqKey="Klein B" first="Barbara E. K." last="Klein">Barbara E. K. Klein</name><affiliation wicri:level="2"><nlm:aff id="A19">Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author><author><name sortKey="Hagstrom, Stephanie A" sort="Hagstrom, Stephanie A" uniqKey="Hagstrom S" first="Stephanie A." last="Hagstrom">Stephanie A. Hagstrom</name><affiliation wicri:level="2"><nlm:aff id="A77">Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cole Eye Institute, Cleveland Clinic, Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Chowers, Itay" sort="Chowers, Itay" uniqKey="Chowers I" first="Itay" last="Chowers">Itay Chowers</name><affiliation wicri:level="1"><nlm:aff id="A71">Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem</wicri:regionArea><wicri:noRegion>Jerusalem</wicri:noRegion></affiliation></author><author><name sortKey="Lotery, Andrew J" sort="Lotery, Andrew J" uniqKey="Lotery A" first="Andrew J." last="Lotery">Andrew J. Lotery</name><affiliation wicri:level="1"><nlm:aff id="A69">Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton</wicri:regionArea><wicri:noRegion>University of Southampton</wicri:noRegion></affiliation></author><author><name sortKey="Leveillard, Thierry" sort="Leveillard, Thierry" uniqKey="Leveillard T" first="Thierry" last="Léveillard">Thierry Léveillard</name><affiliation wicri:level="3"><nlm:aff id="A62">INSERM, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A63">Institut de la Vision, Department of Genetics, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut de la Vision, Department of Genetics, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A64">CNRS, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Zhang, Kang" sort="Zhang, Kang" uniqKey="Zhang K" first="Kang" last="Zhang">Kang Zhang</name><affiliation wicri:level="2"><nlm:aff id="A8">Department of Ophthalmology, University of California San Diego and VA San Diego Health System, La Jolla, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, University of California San Diego and VA San Diego Health System, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A44">Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan</wicri:regionArea><wicri:noRegion>Sichuan</wicri:noRegion></affiliation></author><author><name sortKey="Brilliant, Murray H" sort="Brilliant, Murray H" uniqKey="Brilliant M" first="Murray H." last="Brilliant">Murray H. Brilliant</name><affiliation wicri:level="2"><nlm:aff id="A7">Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, WI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, WI</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author><author><name sortKey="Hewitt, Alex W" sort="Hewitt, Alex W" uniqKey="Hewitt A" first="Alex W." last="Hewitt">Alex W. Hewitt</name><affiliation wicri:level="1"><nlm:aff id="A6">School of Medicine, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>School of Medicine, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania</wicri:regionArea><wicri:noRegion>Tasmania</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A30">Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A41">Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Western Australia, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Western Australia</wicri:regionArea><wicri:noRegion>Western Australia</wicri:noRegion></affiliation></author><author><name sortKey="Swaroop, Anand" sort="Swaroop, Anand" uniqKey="Swaroop A" first="Anand" last="Swaroop">Anand Swaroop</name><affiliation wicri:level="2"><nlm:aff id="A38">Neurobiology Neurodegeneration & Repair Laboratory (N-NRL), National Eye Institute, National Institutes of Health, Bethesda, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Neurobiology Neurodegeneration & Repair Laboratory (N-NRL), National Eye Institute, National Institutes of Health, Bethesda, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Chew, Emily Y" sort="Chew, Emily Y" uniqKey="Chew E" first="Emily Y." last="Chew">Emily Y. Chew</name><affiliation wicri:level="2"><nlm:aff id="A98">Division of Epidemiology and Clinical Applications, Clinical Trials Branch, National Eye Institute, National Institutes of Health, Bethesda, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Epidemiology and Clinical Applications, Clinical Trials Branch, National Eye Institute, National Institutes of Health, Bethesda, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Pericak Vance, Margaret A" sort="Pericak Vance, Margaret A" uniqKey="Pericak Vance M" first="Margaret A." last="Pericak-Vance">Margaret A. Pericak-Vance</name><affiliation wicri:level="2"><nlm:aff id="A22">John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Deangelis, Margaret" sort="Deangelis, Margaret" uniqKey="Deangelis M" first="Margaret" last="Deangelis">Margaret Deangelis</name><affiliation wicri:level="2"><nlm:aff id="A48">Department of Ophthalmology and Visual Sciences, University of Utah, Salt Lake City, UT, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, University of Utah, Salt Lake City, UT</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="Stambolian, Dwight" sort="Stambolian, Dwight" uniqKey="Stambolian D" first="Dwight" last="Stambolian">Dwight Stambolian</name><affiliation wicri:level="2"><nlm:aff id="A10">Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Haines, Jonathan L" sort="Haines, Jonathan L" uniqKey="Haines J" first="Jonathan L." last="Haines">Jonathan L. Haines</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A99">Institute for Computational Biology, Case Western Reserve University School of Medicine, Cleveland, OH, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Computational Biology, Case Western Reserve University School of Medicine, Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Iyengar, Sudha K" sort="Iyengar, Sudha K" uniqKey="Iyengar S" first="Sudha K." last="Iyengar">Sudha K. Iyengar</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Weber, Bernhard H F" sort="Weber, Bernhard H F" uniqKey="Weber B" first="Bernhard H. F." last="Weber">Bernhard H. F. Weber</name><affiliation wicri:level="1"><nlm:aff id="A4">Institute of Human Genetics, University of Regensburg, Regensburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Human Genetics, University of Regensburg, Regensburg</wicri:regionArea><wicri:noRegion>Regensburg</wicri:noRegion><wicri:noRegion>Regensburg</wicri:noRegion><wicri:noRegion>Regensburg</wicri:noRegion></affiliation></author><author><name sortKey="Abecasis, Goncalo R" sort="Abecasis, Goncalo R" uniqKey="Abecasis G" first="Gonçalo R." last="Abecasis">Gonçalo R. Abecasis</name><affiliation wicri:level="2"><nlm:aff id="A1">Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Heid, Iris M" sort="Heid, Iris M" uniqKey="Heid I" first="Iris M." last="Heid">Iris M. Heid</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Genetic Epidemiology, University of Regensburg, Regensburg</wicri:regionArea><wicri:noRegion>Regensburg</wicri:noRegion><wicri:noRegion>Regensburg</wicri:noRegion><wicri:noRegion>Regensburg</wicri:noRegion></affiliation></author></analytic><series><title level="j">Nature genetics</title><idno type="ISSN">1061-4036</idno><idno type="eISSN">1546-1718</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Genetic Predisposition to Disease</term><term>Genome-Wide Association Study</term><term>Humans</term><term>Macular Degeneration (genetics)</term><term>Mutation</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Dégénérescence maculaire (génétique)</term><term>Humains</term><term>Mutation</term><term>Prédisposition génétique à une maladie</term><term>Étude d'association pangénomique</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Macular Degeneration</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Dégénérescence maculaire</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Genetic Predisposition to Disease</term><term>Genome-Wide Association Study</term><term>Humans</term><term>Mutation</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Mutation</term><term>Prédisposition génétique à une maladie</term><term>Étude d'association pangénomique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Advanced age-related macular degeneration (AMD) is the leading cause of blindness in the elderly with limited therapeutic options. Here, we report on a study of >12 million variants including 163,714 directly genotyped, most rare, protein-altering variant. Analyzing 16,144 patients and 17,832 controls, we identify 52 independently associated common and rare variants (P < 5×10<sup>–8</sup>) distributed across 34 loci. While wet and dry AMD subtypes exhibit predominantly shared genetics, we identify the first signal specific to wet AMD, near <italic>MMP9</italic> (difference-P = 4.1×10<sup>–10</sup>). Very rare coding variants (frequency < 0.1%) in <italic>CFH</italic>, <italic>CFI</italic>, and <italic>TIMP3</italic> suggest causal roles for these genes, as does a splice variant in <italic>SLC16A8</italic>. Our results support the hypothesis that rare coding variants can pinpoint causal genes within known genetic loci and illustrate that applying the approach systematically to detect new loci requires extremely large sample sizes.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Smith, W" uniqKey="Smith W">W Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chakravarthy, U" uniqKey="Chakravarthy U">U Chakravarthy</name></author><author><name sortKey="Evans, J" uniqKey="Evans J">J Evans</name></author><author><name sortKey="Rosenfeld, Pj" uniqKey="Rosenfeld P">PJ Rosenfeld</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ferris, Fl" uniqKey="Ferris F">FL Ferris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wong, Wl" uniqKey="Wong W">WL Wong</name></author></analytic></biblStruct><biblStruct><analytic><author><name 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Roeder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stephens, M" uniqKey="Stephens M">M Stephens</name></author><author><name sortKey="Balding, Dj" uniqKey="Balding D">DJ Balding</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Blake, Ja" uniqKey="Blake J">JA Blake</name></author><author><name sortKey="Bult, Cj" uniqKey="Bult C">CJ Bult</name></author><author><name sortKey="Eppig, Jt" uniqKey="Eppig J">JT Eppig</name></author><author><name sortKey="Kadin, Ja" uniqKey="Kadin J">JA Kadin</name></author><author><name sortKey="Richardson, Je" uniqKey="Richardson J">JE Richardson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brown, Sd" uniqKey="Brown S">SD Brown</name></author><author><name sortKey="Moore, Mw" uniqKey="Moore M">MW Moore</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Ph" uniqKey="Lee P">PH Lee</name></author><author><name sortKey="O Dushlaine, C" uniqKey="O Dushlaine C">C O'Dushlaine</name></author><author><name sortKey="Thomas, B" uniqKey="Thomas B">B Thomas</name></author><author><name sortKey="Purcell, Sm" uniqKey="Purcell S">SM Purcell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kanehisa, M" uniqKey="Kanehisa M">M Kanehisa</name></author><author><name sortKey="Goto, S" uniqKey="Goto S">S Goto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Croft, D" uniqKey="Croft D">D Croft</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ashburner, M" uniqKey="Ashburner M">M Ashburner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Law, V" uniqKey="Law V">V Law</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="So, Hc" uniqKey="So H">HC So</name></author><author><name sortKey="Gui, Ah" uniqKey="Gui A">AH Gui</name></author><author><name sortKey="Cherny, Ss" uniqKey="Cherny S">SS Cherny</name></author><author><name sortKey="Sham, Pc" uniqKey="Sham P">PC Sham</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Corée du Sud</li><li>France</li><li>Grèce</li><li>Israël</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Alabama</li><li>Angleterre</li><li>Angleterre de l'Est</li><li>Bavière</li><li>Californie</li><li>Caroline du Nord</li><li>District de Cologne</li><li>District de Haute-Bavière</li><li>Floride</li><li>Grand Londres</li><li>Gueldre</li><li>Hollande-Méridionale</li><li>Maryland</li><li>Massachusetts</li><li>Michigan</li><li>Nouvelle-Galles du Sud</li><li>Ohio</li><li>Oregon</li><li>Pennsylvanie</li><li>Rhénanie-du-Nord-Westphalie</li><li>Région capitale de Séoul</li><li>Tennessee</li><li>Texas</li><li>Utah</li><li>Victoria (État)</li><li>Wisconsin</li><li>Écosse</li><li>État de New York</li><li>Île-de-France</li></region><settlement><li>Bonn</li><li>Cambridge</li><li>Londres</li><li>Melbourne</li><li>Munich</li><li>New York</li><li>Nimègue</li><li>Paris</li><li>Pittsburgh</li><li>Portland</li><li>Rotterdam</li><li>Sydney</li><li>Séoul</li><li>Édimbourg</li></settlement><orgName><li>University College de Londres</li><li>Université Columbia</li><li>Université Pierre-et-Marie-Curie</li><li>Université d'Édimbourg</li><li>Université de Cambridge</li><li>Université de Melbourne</li><li>Université de Pittsburgh</li><li>Université de Sydney</li><li>Université des sciences et de la médecine de l'Oregon</li></orgName></list><tree><country name="États-Unis"><region name="Michigan"><name sortKey="Fritsche, Lars G" sort="Fritsche, Lars G" uniqKey="Fritsche L" first="Lars G." last="Fritsche">Lars G. 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